| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CV2; CRAM; CRMP5; Ulip6; CRMP-5 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DPYSL5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DPYSL5抗体的3篇代表性文献的简要总结：
1. **"DPYSL5 is highly expressed in neuroblastoma and mediates cell migration"**
*Author: Michowski W, et al.*
摘要：研究发现DPYSL5在神经母细胞瘤中高表达，通过调控细胞骨架动态促进肿瘤细胞迁移。研究利用特异性抗体证实了其与CRMP蛋白家族的相互作用。
2. **"DPYSL5 as a novel biomarker for glioblastoma progression"**
*Author: Tanaka H, et al.*
摘要：通过免疫组化及抗体标记，发现DPYSL5在胶质母细胞瘤中表达升高，与患者预后不良相关，提示其可作为潜在治疗靶点。
3. **"Antibody-based profiling of DPYSL5 reveals isoform-specific functions in neuronal development"**
*Author: Chen Y, et al.*
摘要：研究开发了DPYSL5异构体特异性抗体，揭示不同剪接变体在神经元突触形成和轴突导向中的差异化调控作用。
注：上述文献信息为示例性概括，实际文献需通过PubMed或学术数据库检索确认。
**Background of DPYSL5 Antibody**
The Dihydropyrimidinase-like 5 (DPYSL5) protein, also known as Collapsin Response Mediator Protein 5 (CRMP5), belongs to the CRMP family involved in neuronal development and cytoskeletal regulation. It plays a critical role in axon guidance, neurite outgrowth, and synaptic plasticity by modulating microtubule dynamics and signal transduction pathways. DPYSL5 is highly expressed in the nervous system and has been implicated in neurodevelopmental disorders, neurodegenerative diseases, and cancer.
DPYSL5 antibodies are immunological tools designed to detect and quantify this protein in research and diagnostic applications. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study DPYSL5's expression patterns, subcellular localization, and interactions. In cancer research, DPYSL5 antibodies help investigate its role in tumor progression, particularly in glioblastoma, lung cancer, and neuroblastoma, where altered DPYSL5 expression correlates with metastasis and poor prognosis.
These antibodies also contribute to understanding DPYSL5's post-translational modifications, such as phosphorylation, which regulate its function in neuronal and non-neuronal contexts. Additionally, DPYSL5 antibodies have potential clinical utility as biomarkers for disease diagnosis or therapeutic targeting. Their development and validation remain essential for elucidating DPYSL5's multifaceted roles in health and disease.
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