| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | BAR, B2AR, ADRBR, ADRB2R, BETA2AR |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ADRB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADRB2抗体的3篇参考文献示例(内容基于公开研究归纳，非真实文献)：
1. **文献名称**：*ADRB2 Expression in Airway Smooth Muscle: Role of Antibody-Based Detection in Asthma*
**作者**：Smith J, et al.
**摘要**：研究利用ADRB2特异性抗体分析哮喘患者气道平滑肌中ADRB2蛋白的表达水平，发现其表达降低与β激动剂耐药性相关。
2. **文献名称**：*Structural Mapping of ADRB2 Epitopes via Monoclonal Antibody Screening*
**作者**：Lee H, et al.
**摘要**：通过开发多种抗ADRB2单克隆抗体，揭示受体胞外域的关键表位，为靶向药物设计提供结构生物学依据。
3. **文献名称**：*ADRB2 Genetic Variants Alter Antibody Binding Efficiency in Cell Lines*
**作者**：Garcia R, et al.
**摘要**：探讨ADRB2基因多态性(如Arg16Gly)对抗体结合能力的影响，发现特定突变导致免疫检测信号差异，提示临床检测需考虑基因背景。
(注：以上为模拟内容，实际文献需通过学术数据库查询。)
The ADRB2 antibody targets the beta-2 adrenergic receptor (ADRB2), a G protein-coupled receptor (GPCR) widely expressed in smooth muscle cells (e.g., airways, blood vessels, uterus) and other tissues. ADRB2 plays a critical role in mediating physiological responses to catecholamines like adrenaline and noradrenaline, regulating processes such as bronchodilation, vasodilation, and metabolism. Dysregulation of ADRB2 is linked to asthma, cardiovascular diseases, obesity, and diabetes.
ADRB2 antibodies are essential tools for studying receptor expression, localization, and signaling in research and diagnostics. They help investigate ADRB2's role in diseases and assess therapeutic responses to beta-2 agonists (e.g., salmeterol for asthma) or antagonists. Additionally, these antibodies aid in exploring genetic polymorphisms (e.g., Arg16Gly) that influence receptor function and drug efficacy.
Common applications include immunohistochemistry, flow cytometry, and Western blotting to quantify ADRB2 levels in tissues or cells. In drug discovery, they screen compounds targeting ADRB2 to develop therapies with improved specificity. As a biomarker, ADRB2 expression may correlate with disease severity or treatment outcomes. Overall, ADRB2 antibodies are vital for advancing research on GPCR biology, personalized medicine, and respiratory or metabolic disorder therapeutics.
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