| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human RAB22A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及RAB22A抗体的相关文献摘要：
1. **文献名称**: "RAB22A promotes tumor metastasis by regulating vesicular trafficking"
**作者**: Wang T, et al.
**摘要**: 研究揭示了RAB22A通过调控内体膜泡运输促进肿瘤细胞迁移和侵袭的机制，并利用特异性抗体验证了其在乳腺癌中的高表达与患者预后不良相关。
2. **文献名称**: "Rab22a enhances autophagy-mediated survival and metastasis in hepatocellular carcinoma"
**作者**: Liu Z, et al.
**摘要**: 通过免疫组化(使用RAB22A抗体)和功能实验，证明RAB22A通过激活自噬途径维持肝癌细胞存活，且其过表达与肝癌转移显著相关。
3. **文献名称**: "RAB22A as a novel biomarker for glioblastoma progression"
**作者**: Chen J, et al.
**摘要**: 研究利用RAB22A特异性抗体进行组织染色，发现其在胶质母细胞瘤中异常高表达，并通过调控EGFR信号通路促进肿瘤血管生成和侵袭。
*注：以上文献为示例性质，实际引用需核对PubMed/Web of Science等数据库获取完整信息。建议补充检索关键词"RAB22A antibody validation"或"RAB22A immunohistochemistry"获取更具体的抗体应用文献。*
**Background of RAB22A Antibody**
RAB22A, a member of the Rab GTPase family, plays a critical role in regulating intracellular membrane trafficking, particularly in endosomal sorting and recycling. It is implicated in diverse cellular processes, including vesicle formation, cargo transport, and autophagy. Dysregulation of RAB22A has been linked to cancer progression, where it promotes tumor invasion, metastasis, and chemoresistance by modulating pathways like EGFR recycling and TGF-β signaling. Its overexpression is observed in multiple cancers, such as breast, liver, and ovarian cancers, making it a potential therapeutic target.
RAB22A antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect RAB22A protein levels in cells or tissues. Researchers also employ them to investigate RAB22A's interaction partners and its role in oncogenic processes or neurodegenerative diseases. Recent studies highlight its involvement in autophagosome-lysosome fusion and pathogen infection mechanisms, expanding its relevance in biomedical research. Developing specific and validated RAB22A antibodies remains crucial for advancing understanding of its molecular mechanisms and exploring targeted therapies.
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