| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PDCD12 |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human AVEN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AVEN抗体的3篇代表性文献示例(内容为模拟，非真实文献)：
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1. **文献名称**：*AVEN: A Novel Apoptosis Inhibitor in the BCL-2 Pathway*
**作者**：Chau, B.N., et al.
**摘要**：该研究首次报道AVEN蛋白作为BCL-2家族凋亡调控通路中的新成员，通过结合APAF-1和BCL-xL抑制caspase-9的活化，从而阻断细胞凋亡。
2. **文献名称**：*Expression and Prognostic Significance of AVEN in Acute Myeloid Leukemia*
**作者**：Wang, Y., et al.
**摘要**：分析AVEN在急性髓系白血病中的高表达现象，发现其与患者化疗耐药性相关，提示AVEN可能作为潜在预后标志物。
3. **文献名称**：*Structural Insights into AVEN-Mediated Caspase Inhibition*
**作者**：Zhang, L., et al.
**摘要**：通过晶体学解析AVEN与caspase-9的相互作用结构，阐明其通过阻断凋亡体形成抑制凋亡的分子机制。
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**注**：以上文献信息为模拟示例，实际研究中请通过PubMed或专业数据库(如Google Scholar)以关键词“AVEN apoptosis”或“AVEN antibody”检索最新文献。
AVEN antibody is a research tool targeting the AVEN protein, a regulator of apoptosis initially identified for its role in inhibiting programmed cell death. AVEN (Apoptosis and VSV-Expressing Protein) interacts with apoptotic protease-activating factor-1 (Apaf-1), a key component of the mitochondrial apoptosis pathway. By binding to Apaf-1. AVEN prevents the formation of the apoptosome, a multiprotein complex that activates caspase-9 and initiates the caspase cascade, ultimately suppressing apoptosis. This mechanism highlights AVEN's importance in cellular survival, particularly under stress conditions.
AVEN antibodies are primarily used in studies exploring apoptosis regulation, cancer biology, and neurodegenerative diseases. In cancer research, elevated AVEN expression has been linked to tumor progression and chemotherapy resistance, making it a potential therapeutic target. Antibodies against AVEN enable detection and quantification of the protein via techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding in investigations of its expression patterns and functional roles.
Recent studies also suggest AVEN's involvement in DNA damage responses and autophagy, expanding its relevance beyond apoptosis. Researchers utilize AVEN antibodies to dissect these pathways in both in vitro and in vivo models. Commercial AVEN antibodies are typically raised in rabbits or mice, with specificity validated using knockout controls. As interest grows in targeting survival pathways for disease treatment, AVEN remains a focal point, and its antibodies continue to support advances in understanding cell death regulation and developing targeted therapies.
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