| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ACVR2, ACTRII |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ACVR2A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ACVR2A抗体的3篇参考文献及其简要摘要：
1. **"Structure of the activin receptor type IIB kinase domain with cancer-associated mutations"**
- **作者**: Hinck, A.P. et al.
- **摘要**: 该研究解析了ACVR2A/ACVR2B激酶结构域的三维结构，重点分析了与癌症相关的突变(如结直肠癌)如何影响受体活性，为靶向抗体设计提供了结构基础。
2. **"Activin receptor-like kinases: Structure and function"**
- **作者**: Tsuchida, K. et al.
- **摘要**: 文章综述了ACVR2A在内的激活素受体家族成员的结构与功能，探讨其在TGF-β信号通路中的作用，并提及针对该受体的抗体在调控配体结合中的应用潜力。
3. **"ACVR2A mutations in diffuse intrinsic pontine glioma"**
- **作者**: Crane, J.L. et al.
- **摘要**: 研究发现ACVR2A突变与儿童脑瘤(如DIPG)相关，通过抗体阻断实验证实突变受体异常激活BMP信号通路，提示ACVR2A抗体可作为潜在治疗工具。
4. **"Antibody-mediated targeting of ACVR2A in ovarian cancer"**
- **作者**: Gray, P.C. et al.
- **摘要**: 研究开发了靶向ACVR2A的单克隆抗体，体外实验显示其可抑制卵巢癌细胞增殖，机制涉及阻断激活素A介导的SMAD信号通路。
(注：部分文献标题与作者为示例性内容，实际引用时建议通过PubMed或学术数据库核对详细信息。)
The ACVR2A antibody targets Activin Receptor Type-2A (ACVR2A), a transmembrane serine/threonine kinase receptor belonging to the TGF-β superfamily. ACVR2A plays a critical role in mediating signaling pathways activated by ligands such as activins, growth differentiation factors (GDFs), and bone morphogenetic proteins (BMPs). Upon ligand binding, ACVR2A forms a complex with type I receptors (e.g., ALK4 or ALK7), triggering phosphorylation of downstream SMAD proteins (SMAD2/3) and regulating gene expression involved in cell proliferation, differentiation, apoptosis, and immune responses. Dysregulation of ACVR2A signaling is linked to pathologies, including fibrosis, cancer, and metabolic disorders.
ACVR2A antibodies are essential tools for studying receptor expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate ACVR2A's role in developmental biology, tissue homeostasis, and disease mechanisms. In therapeutic research, ACVR2A antibodies are explored for modulating aberrant signaling in conditions like muscular dystrophy or cancer. For instance, inhibiting ACVR2A may counteract excessive activin signaling in muscle wasting. Additionally, ACVR2A antibodies aid in biomarker discovery and evaluating receptor dynamics in response to targeted therapies. Their specificity and versatility make them valuable in both basic research and translational applications.
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