| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | BMP-3A |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human BMP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BMP3抗体的示例文献(内容为模拟生成，非真实文献，建议通过学术数据库核实)：
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1. **文献名称**：Development of a High-Specificity Monoclonal Antibody for BMP3 Detection
**作者**：Smith A, et al.
**摘要**：研究团队开发了一种针对BMP3的单克隆抗体，通过免疫印迹和免疫组化验证其特异性，证实其在骨组织及肿瘤样本中的检测潜力。
2. **文献名称**：BMP3 as a Serum Biomarker in Colorectal Cancer: Validation Using a Novel ELISA Assay
**作者**：Chen L, et al.
**摘要**：该文献建立了一种基于BMP3抗体的ELISA检测方法，证明血清BMP3水平与结直肠癌进展相关，可能成为诊断标志物。
3. **文献名称**：Role of BMP3 in Osteogenesis: Insights from Antibody-Mediated Functional Blockade
**作者**：Yamamoto K, et al.
**摘要**：通过抗BMP3抗体阻断实验，揭示BMP3在成骨细胞分化中的抑制作用，为骨代谢疾病机制提供新视角。
4. **文献名称**：Comparative Analysis of Commercial BMP3 Antibodies for Research Applications
**作者**：Johnson R, et al.
**摘要**：系统评估了多种市售BMP3抗体的灵敏度和交叉反应性，为实验选择提供参考依据。
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建议通过PubMed、Web of Science等平台，以关键词“BMP3 antibody”、“BMP3 immunoassay”检索最新文献。
**Background of BMP3 Antibody**
Bone morphogenetic protein 3 (BMP3), a member of the TGF-β superfamily, plays a unique role in regulating cellular processes such as differentiation, apoptosis, and skeletal development. Unlike other BMPs that promote osteogenesis, BMP3 acts as a negative regulator of bone formation, modulating signaling pathways like BMP-Smad and MAPK. Its expression is observed in various tissues, including bone, cartilage, and nervous system, with emerging roles in cancer, where it may suppress tumor growth or act context-dependently.
BMP3 antibodies are critical tools for detecting and quantifying BMP3 protein levels in research. They enable studies on BMP3’s expression patterns, interactions, and functional mechanisms. These antibodies are typically developed in hosts like rabbits or mice, using immunogens derived from specific BMP3 epitopes. Validated applications include Western blotting, immunohistochemistry (IHC), and ELISA, often accompanied by knockout controls to confirm specificity.
Research applications span developmental biology, bone disease studies (e.g., osteoporosis), and cancer biology, where BMP3’s dual roles in tumor suppression and progression are under investigation. Additionally, BMP3 antibodies contribute to exploring therapeutic strategies, such as targeting BMP3 signaling in regenerative medicine. Commercial variants may differ in reactivity (human, mouse, rat) and clonality (monoclonal/polyoclonal), necessitating careful selection based on experimental needs.
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