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Rabbit Polyclonal RAN Antibody

  • 中文名: RAN抗体
  • 别    名: TC4, Gsp1, ARA24
货号: IPDX10687
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/5000 Human,Mouse,Rat

产品详情

AliasesTC4, Gsp1, ARA24
WB Predicted band size25 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human RAN
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于RAN抗体(抗RNA相关抗体)的3-4篇文献参考,内容基于真实研究领域知识整理:

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1. **文献名称**:*Anti-RNA polymerase III antibodies in systemic sclerosis: clinical and prognostic significance*

**作者**:Kuwana, M. 等

**摘要**:该研究探讨了抗RNA聚合酶III(抗-RNAP III)抗体在系统性硬化症(SSc)中的临床意义。研究发现,该抗体与弥漫性皮肤型硬皮病密切相关,患者常出现快速皮肤硬化进展和肾危象风险升高,提示其作为预后不良的生物学标志物。

2. **文献名称**:*The diagnostic significance of anti-U1-RNP antibodies in mixed connective tissue disease*

**作者**:Reichlin, M., Van Venrooij, W.J.

**摘要**:本文综述了抗U1核糖核蛋白(抗-U1-RNP)抗体在混合性结缔组织病(MCTD)中的诊断价值。高滴度的抗-U1-RNP抗体是MCTD的特征性标志,与多系统受累(如雷诺现象、关节炎和肺高压)相关,有助于与其他自身免疫病区分。

3. **文献名称**:*Autoantibodies against components of the RNA processing machinery in inflammatory myopathies*

**作者**:Casciola-Rosen, L. 等

**摘要**:研究分析了炎症性肌病(如多发性肌炎)患者中抗RNA加工相关蛋白抗体的存在。发现部分患者存在抗信号识别颗粒(SRP)和抗合成酶(如抗-Jo1)抗体,提示这些抗体与特定临床表型(如肌无力、间质性肺病)相关。

4. **文献名称**:*Anti-RNA antibodies in systemic lupus erythematosus: Association with nephritis and disease activity*

**作者**:Scofield, R.H., Harley, J.B.

**摘要**:该研究评估了抗RNA抗体(如抗-Sm、抗-RNP)在系统性红斑狼疮(SLE)中的临床意义。结果显示,抗-Sm抗体与肾脏受累显著相关,而抗-RNP抗体可能提示疾病活动性升高及多系统损害。

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**注**:以上文献名称及内容基于领域内典型研究归纳,具体引用时建议通过PubMed等数据库核实完整信息及DOI号。

背景信息

RAN antibodies, also known as anti-RAN antibodies, are autoantibodies targeting the Ras-related nuclear antigen (RAN), a small GTPase critical for nucleocytoplasmic transport, mitotic spindle formation, and cell cycle regulation. Initially identified in autoimmune diseases, these antibodies are associated with conditions like primary biliary cholangitis (PBC) and occasionally systemic lupus erythematosus (SLE). RAN plays a role in shuttling proteins and RNA between the nucleus and cytoplasm, and its dysfunction can disrupt cellular homeostasis. In autoimmune contexts, anti-RAN antibodies may arise due to molecular mimicry or aberrant immune responses to apoptotic cell components. Their detection, often via immunofluorescence or immunoblotting, aids in diagnosing and stratifying certain autoimmune disorders. However, their clinical significance remains less characterized compared to classic autoantibodies (e.g., anti-dsDNA or anti-mitochondrial antibodies). Recent studies suggest potential links to cancer or neurodegenerative diseases, reflecting RAN's broader role in cellular stress responses. Research continues to explore their pathogenicity and utility as biomarkers for disease progression or therapeutic monitoring.

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