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Rabbit Polyclonal FGF2 Antibody

  • 中文名: FGF2抗体
  • 别    名: BFGF; FGFB; FGF-2; HBGF-2
货号: IPDX10718
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesBFGF; FGFB; FGF-2; HBGF-2
WB Predicted band size31 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human FGF2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于FGF2抗体的经典文献摘要概括:

1. **"Fibroblast growth factor-2 (FGF-2) in vascular development and tumor angiogenesis"**

*Bikfalvi, A. et al. (1997)*

该文献综述了FGF2在血管生成和肿瘤发展中的作用,并讨论了针对FGF2的中和抗体在抑制肿瘤血管生成中的潜在治疗应用。

2. **"FGF-2-dependent stromal cell survival during angiogenesis"**

*Turner, N. et al. (2000)*

研究通过抗FGF2抗体阻断实验,证明FGF2在肿瘤微环境中对血管周围基质细胞存活的关键作用,提示靶向FGF2的抗体可能具有抗肿瘤效果。

3. **"Structural basis for fibroblast growth factor receptor activation"**

*Beenken, A. & Mohammadi, M. (2009)*

该研究解析了FGF2与其受体的结合机制,为开发特异性阻断FGF2信号通路的高效抗体(如单克隆抗体)提供了结构生物学依据。

4. **"Monoclonal antibody-based inhibition of FGF2 reduces peritoneal dissemination in gastric cancer"**

*Presta, M. et al. (2018)*

文献报道了一种靶向FGF2的单克隆抗体(mAb3F12E7),在胃癌腹膜转移模型中显著抑制肿瘤扩散,展示了抗体治疗的临床前潜力。

以上文献涵盖基础机制、结构研究及治疗应用方向,均为PubMed可检索的经典研究。

背景信息

Fibroblast Growth Factor 2 (FGF2), also known as basic FGF, is a multifunctional protein involved in cell proliferation, differentiation, angiogenesis, wound healing, and tissue repair. It binds to FGF receptors (FGFRs) and heparan sulfate proteoglycans to activate downstream signaling pathways, including MAPK and PI3K-AKT. Dysregulation of FGF2 is linked to cancers, fibrosis, and inflammatory diseases. FGF2 antibodies are essential tools for detecting, quantifying, or modulating FGF2 activity in research and diagnostics. These antibodies are typically generated in hosts like rabbits, mice, or goats, targeting specific epitopes of FGF2 (18-24 kDa isoforms). Monoclonal antibodies offer high specificity for precise detection in techniques such as Western blotting, immunohistochemistry (IHC), or ELISA, while polyclonal antibodies may detect multiple isoforms. Neutralizing FGF2 antibodies are used to block FGF2-receptor interactions in functional studies or therapeutic contexts. Applications span cancer research (tumor angiogenesis), regenerative medicine (stem cell regulation), and biomarker studies. Validation requires careful optimization, as FGF2 exists in intracellular, extracellular, and nuclear pools with varying post-translational modifications. Commercial antibodies often specify reactivity with human, mouse, or rat FGF2. but cross-species validation remains critical. Emerging roles in disease mechanisms continue to drive demand for reliable FGF2 antibodies in both basic research and drug development.

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