| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/5000 | Human,Mouse,Rat |
| Aliases | CPT1, IIAE4, CPTASE |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CPT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CPT2抗体的参考文献示例(注：以下内容为模拟概括，非真实文献)：
1. **标题**：*Immunoblot Analysis of Carnitine Palitoyltransferase II Deficiency Using Novel CPT2 Antibodies*
**作者**：Bonnefont JP, et al.
**摘要**：开发并验证了针对CPT2蛋白的特异性抗体，用于通过免疫印迹技术诊断遗传性CPT2缺乏症，提高了新生儿筛查和成人病例的确诊效率。
2. **标题**：*Characterization of CPT2-Specific Monoclonal Antibodies for Metabolic Disorder Research*
**作者**：Isackson PJ, et al.
**摘要**：研究比较了多种CPT2单克隆抗体的特异性与灵敏度，证实其在肌肉和肝脏组织中的靶向结合能力，支持其在脂肪酸氧化代谢研究中的应用。
3. **标题**：*Immunohistochemical Localization of CPT2 in Human Skeletal Muscle: Implications for Lipid Storage Myopathies*
**作者**：Bersch B, et al.
**摘要**：利用CPT2抗体对肌肉活检样本进行免疫组化分析，揭示了CPT2表达异常与脂质沉积性肌病的相关性，为病理机制研究提供依据。
4. **标题**：*Development of a High-Sensitivity CPT2 Antibody for Early Detection of Metabolic Dysfunction*
**作者**：Alvarez R, et al.
**摘要**：报道了一种高灵敏度的CPT2抗体，通过ELISA和流式细胞术检测低表达样本，推动了对亚临床代谢功能障碍的早期诊断。
(注：以上文献及作者为示例性质，实际引用请以真实数据库检索结果为准。)
**Background of CPT2 Antibody**
Carnitine palmitoyltransferase 2 (CPT2) is a mitochondrial enzyme critical for fatty acid oxidation, facilitating the transport of long-chain fatty acids into the mitochondrial matrix for energy production. The CPT2 antibody is a key tool for detecting and studying this enzyme in research and diagnostics.
CPT2 deficiency, a rare autosomal recessive disorder, disrupts fatty acid metabolism, leading to metabolic crises, muscle weakness, or hepatic dysfunction. Studying CPT2 expression and function using specific antibodies helps elucidate disease mechanisms and improve diagnostic accuracy.
Commercially available CPT2 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the human or murine CPT2 protein. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression levels in tissues (e.g., liver, muscle) or cell lines. Validated antibodies undergo rigorous testing (e.g., knockout controls, mass spectrometry) to ensure specificity, minimizing cross-reactivity with related enzymes like CPT1.
In research, CPT2 antibodies contribute to studies on metabolic diseases, cancer (where altered fatty acid metabolism supports tumor growth), and drug development. Their standardized use enhances reproducibility in both basic and clinical research, bridging molecular insights with therapeutic applications.
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