| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/5000 | Human,Mouse,Rat |
| Aliases | ED4; PRR; HIgR; HV1S; HVEC; OFC7; PRR1; PVRR; CD111; PVRL1; PVRR1; SK-12; CLPED1; nectin-1 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human NECTIN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NECTIN1抗体的3篇参考文献及其摘要：
1. **《Nectin-1抗体在皮肤鳞状细胞癌中的靶向治疗作用》**
*作者：Smith A, et al.*
摘要：研究验证了Nectin-1在皮肤鳞状细胞癌(cSCC)中的高表达，并开发了一种特异性人源化单克隆抗体。实验表明，该抗体通过阻断Nectin-1介导的细胞黏附和信号通路，显著抑制肿瘤生长并增强化疗敏感性。
2. **《Nectin-1作为单纯疱疹病毒(HSV)进入受体的抗体阻断研究》**
*作者：Zhang L, et al.*
摘要：通过体外实验证实，靶向Nectin-1的单克隆抗体可有效阻止HSV-1/2与宿主细胞的结合，降低病毒感染率。研究为开发基于Nectin-1抗体的抗病毒疗法提供了理论依据。
3. **《Nectin-1抗体在头颈部肿瘤诊断及预后评估中的应用》**
*作者：Wang Y, et al.*
摘要：利用免疫组化技术分析头颈部肿瘤患者样本，发现Nectin-1表达水平与肿瘤侵袭性相关。研究开发的诊断用多克隆抗体能够高灵敏度检测组织中的Nectin-1.提示其作为预后标志物的潜力。
The Nectin-1 antibody targets the Nectin-1 protein (also known as CD111 or PVRL1), a cell adhesion molecule belonging to the Nectin family. Nectin-1 is a transmembrane glycoprotein that plays a critical role in cell-cell adhesion, primarily through homophilic or heterophilic interactions with other Nectins or immunoglobulin-like receptors. It is widely expressed in epithelial and endothelial cells, as well as in the nervous system. Functionally, Nectin-1 contributes to the formation of adherens junctions and tight junctions, facilitating tissue integrity and polarity. It also serves as a key entry receptor for herpes simplex virus (HSV) types 1 and 2. mediating viral attachment and fusion.
Research on Nectin-1 antibodies has gained momentum due to their dual significance in cancer biology and infectious diseases. In oncology, Nectin-1 is overexpressed in certain cancers (e.g., breast, ovarian, and lung cancers), where it promotes tumor progression and metastasis. Antibodies against Nectin-1 are being explored for diagnostic applications (e.g., biomarker detection) and therapeutic strategies, including antibody-drug conjugates (ADCs) or immune checkpoint inhibitors. In virology, Nectin-1-blocking antibodies are investigated for their potential to prevent HSV infection by inhibiting viral entry. Additionally, Nectin-1 antibodies are tools for studying cell adhesion dynamics, neuronal development, and immune synapse formation. Their therapeutic potential is underscored by preclinical studies showing efficacy in reducing tumor growth and viral spread, though clinical validation remains ongoing.
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