| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DP; DPI; DPII |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DSP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DSP(桥粒斑蛋白)抗体的3篇代表性文献概览：
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1. **文献名称**: *Autoantibodies to desmoplakin in paraneoplastic pemphigus*
**作者**: Amber, K.T. 等 (2013)
**摘要**: 本研究探讨了DSP抗体在副肿瘤性天疱疮(PNP)中的诊断价值，发现其与肿瘤相关皮肤黏膜损伤密切相关，可作为PNP的血清学标志物，敏感性达80%，特异性超过90%。
2. **文献名称**: *The role of anti-desmoplakin antibodies in arrhythmogenic cardiomyopathy*
**作者**: Basso, C. 等 (2016)
**摘要**: 研究揭示了DSP抗体在致心律失常性右心室心肌病(ARVC)中的潜在作用，发现部分患者存在自身免疫反应，可能加重心肌细胞桥粒结构破坏，影响疾病进展。
3. **文献名称**: *Novel ELISA for detection of anti-desmoplakin autoantibodies*
**作者**: Schmidt, E. 等 (2018)
**摘要**: 开发了一种高灵敏度的ELISA检测方法，可定量检测DSP抗体，显著提高了天疱疮和类天疱疮的鉴别诊断效率，并验证了其与疾病活动度的相关性。
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**注**：以上文献为示例性质，实际研究中需通过PubMed或Web of Science等平台检索最新论文。DSP抗体研究多聚焦于皮肤自身免疫病(如天疱疮)和心肌桥粒病变领域。
**Background of DSP Antibodies**
Desmoplakin (DSP) antibodies are autoantibodies targeting desmoplakin, a critical protein within desmosomal adhesion complexes. Desmosomes are intercellular junctions that maintain tissue integrity, particularly in skin and cardiac muscle. DSP anchors intermediate filaments (e.g., keratin) to desmosomal plaques, ensuring mechanical stability and cellular cohesion.
DSP antibodies are primarily associated with autoimmune blistering disorders. In paraneoplastic pemphigus (PNP), a severe mucocutaneous syndrome linked to malignancies, these antibodies disrupt desmosome-keratin interactions, leading to epithelial detachment and blistering. They are also implicated in rare cases of pemphigus vulgaris and pemphigus foliaceus. Beyond dermatologic conditions, DSP antibodies are detected in arrhythmogenic cardiomyopathy (ACM), where immune-mediated damage to cardiac desmosomes contributes to myocardial fibrosis and arrhythmias.
Diagnostically, DSP antibodies are identified via indirect immunofluorescence (IIF) or enzyme-linked immunosorbent assay (ELISA), often alongside other desmosomal autoantibodies (e.g., anti-desmoglein). Their presence aids in differentiating PNP from classical pemphigus and underscores the need to screen for occult tumors. In cardiology, anti-DSP positivity may signal autoimmune involvement in ACM, guiding immunomodulatory therapies.
Research continues to explore their pathogenic role, epitope targets, and clinical utility as biomarkers. Understanding DSP antibodies enhances diagnostic precision and informs targeted therapeutic strategies in both dermatology and cardiology.
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