| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DVL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DVL2抗体的3篇参考文献的简要信息(注：文献信息为模拟示例，实际引用需核实原文)：
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1. **文献名称**: *"DVL2 Antibody Validation in Wnt Signaling Studies"*
**作者**: Smith A, et al.
**摘要**: 该研究验证了DVL2抗体在Western blot和免疫荧光中的特异性，确认其能有效区分DVL1、DVL2和DVL3亚型，并用于探究DVL2在Wnt/β-catenin通路中的定位及功能。
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2. **文献名称**: *"Role of DVL2 in Colorectal Cancer Progression"*
**作者**: Chen L, et al.
**摘要**: 通过DVL2抗体进行免疫组化分析，发现DVL2在结直肠癌组织中高表达，且与β-catenin核易位相关，提示其可作为癌症治疗的潜在靶点。
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3. **文献名称**: *"DVL2 Antibody Application in Neural Development Models"*
**作者**: Yamada R, et al.
**摘要**: 利用DVL2抗体在小鼠胚胎神经管中检测到DVL2蛋白的动态表达，揭示了其在神经嵴细胞迁移和Planar Cell Polarity(PCP)通路中的关键作用。
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如需具体文献，建议在PubMed或Google Scholar中搜索关键词“DVL2 antibody”、“Dishevelled-2 antibody”及“Wnt signaling”获取最新研究。
The Dishevelled (DVL) family of proteins, including DVL2. are key regulators of Wnt signaling pathways, which play critical roles in embryonic development, tissue homeostasis, and disease. DVL2. one of three mammalian paralogs (DVL1-3), acts as a scaffold protein mediating both canonical (β-catenin-dependent) and non-canonical (e.g., planar cell polarity) Wnt signaling. It interacts with receptors like Frizzled to relay signals, influencing cell proliferation, differentiation, and polarity. Antibodies targeting DVL2 are essential tools for studying its expression, localization, and function in these pathways.
DVL2 antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate Wnt-related mechanisms in developmental biology, cancer research (e.g., tumorigenesis, metastasis), and diseases like skeletal disorders or neurological conditions. Due to high homology among DVL isoforms, antibody specificity is a critical consideration; many commercial DVL2 antibodies are validated to minimize cross-reactivity with DVL1 or DVL3. Dysregulation of DVL2 is linked to cancers (e.g., colorectal, breast) and congenital anomalies, making these antibodies valuable for diagnostic or therapeutic research. Recent studies also explore DVL2's role in ciliopathies and regenerative medicine. Researchers often pair DVL2 antibodies with pathway inhibitors or activators to dissect its context-dependent roles in Wnt signaling crosstalk.
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