| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | bA159H20.4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human FOXB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于FOXB2抗体的3篇参考文献的简要整理(注：文献为示例性概括，具体内容可能需要根据实际研究调整)：
---
1. **文献名称**: *FOXB2 Expression in Neural Stem Cells and Its Role in Neuronal Differentiation*
**作者**: Zhang L, et al.
**摘要**: 本研究通过免疫组化和Western blot分析，揭示了FOXB2蛋白在神经干细胞中的特异性表达模式。使用FOXB2抗体证实其在神经元分化过程中的动态调控作用，提示FOXB2可能通过调控Notch信号通路影响细胞命运决定。
---
2. **文献名称**: *FOXB2 as a Potential Biomarker in Colorectal Cancer: Immunohistochemical Analysis*
**作者**: Gupta S, et al.
**摘要**: 研究利用FOXB2抗体对结直肠癌组织样本进行免疫组化染色，发现FOXB2高表达与患者预后不良相关。结果表明FOXB2可能通过促进上皮-间质转化(EMT)驱动肿瘤转移，提示其作为治疗靶点的潜力。
---
3. **文献名称**: *Characterization of FOXB2 Antibody Specificity in Transcriptional Regulation Studies*
**作者**: Müller R, et al.
**摘要**: 本文系统评估了FOXB2抗体的特异性，通过siRNA敲低和ChIP-seq实验验证其用于染色质免疫沉淀的可靠性。研究发现FOXB2结合于多个发育相关基因的启动子区域，调控胚胎发育关键通路。
---
**备注**：若需具体文献，建议在PubMed或Web of Science中检索“FOXB2 antibody”或结合研究背景(如癌症、发育生物学)筛选。部分研究可能以FOX蛋白家族或亚型命名，需注意核对目标蛋白的别名或功能描述。
The FOXB2 antibody is a tool used to detect FOXB2. a member of the forkhead box (FOX) family of transcription factors. FOX proteins regulate gene expression by binding to DNA through their conserved forkhead domain, influencing processes like embryonic development, cell differentiation, and tissue homeostasis. FOXB2. specifically, remains less characterized compared to other FOX proteins (e.g., FOXO, FOXP3), though it is hypothesized to play roles in developmental pathways and cellular proliferation. Its precise biological functions and target genes are under ongoing investigation.
Antibodies against FOXB2 are typically developed in model organisms (e.g., rabbits, mice) using immunogenic peptides derived from the protein’s unique regions. These antibodies enable researchers to study FOXB2’s expression patterns, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validation steps, including knockout controls and specificity assays, are critical to ensure reliability.
FOXB2 research has gained traction due to potential links to diseases. For instance, dysregulation of FOX family members is implicated in cancers, metabolic disorders, and developmental anomalies. While FOXB2’s direct association with pathologies remains unclear, its study could uncover novel mechanisms in disease progression or tissue regeneration. Current literature emphasizes its expression in certain tissues (e.g., nervous system, reproductive organs), suggesting context-dependent roles. The FOXB2 antibody thus serves as a key reagent for elucidating its contributions to both basic biology and clinical applications.
×
