关键信息
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基因名
MPND
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简介
MPND protein is a possible protease that acts as a sensor for N(6)-methyladenosine methylation on DNA (m6A). It recognizes and binds m6A DNA, causing target DNA degradation. MPND Protein, Human (GST) is the recombinant human-derived MPND protein, expressed by E. coli , with N-GST labeled tag.
- 应用
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别名
MPND; MPN domain-containing protein
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种属
Human
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表达系统
E. coli
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标签
N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N594
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表达区间
M1-S471
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The study of MPND (Myeloid-derived suppressor cell Protein with a N-terminal PH domain) recombinant proteins has garnered significant interest due to their critical role in immune regulation and potential implications in cancer therapy. MPND is known to be involved in the modulation of myeloid-derived suppressor cells (MDSCs), which play a pivotal role in suppressing anti-tumor immunity. These proteins have been implicated in various pathological conditions, including inflammation and tumor progression, where they may inhibit T-cell activation and promote tumor growth. Research focusing on the structural and functional characterization of MPND recombinant proteins aims to elucidate their mechanisms of action in immune modulation. This knowledge could lead to novel therapeutic strategies targeting MPND in cancer, potentially enhancing the efficacy of immunotherapies. Furthermore, understanding the interactions and pathways involved in the MPND-mediated suppression can provide insights into the tumor microenvironment and its influence on immune escape. Consequently, the development of MPND-targeted therapies could improve patient outcomes by reinvigorating anti-tumor immunity and overcoming resistance to current treatments. As research progresses, MPND recombinant proteins are positioned as promising candidates for advancing cancer immunotherapy and improving our understanding of immune evasion mechanisms.
