| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | LD; MFH1; MFH-1; FKHL14 |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human FOXC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于FOXC2抗体的虚构参考文献示例(基于常见研究方向概括，非真实文献)：
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1. **文献名称**: *FOXC2 Antibody Validation in Epithelial-Mesenchymal Transition Models*
**作者**: Smith J. et al.
**摘要**: 本研究通过Western blot和免疫组化验证了FOXC2抗体在乳腺癌细胞系中的特异性，证明其在检测EMT过程中FOXC2蛋白表达上调的可靠性，并关联其表达水平与肿瘤转移潜能。
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2. **文献名称**: *FOXC2 as a Biomarker in Triple-Negative Breast Cancer: Antibody-Based Profiling*
**作者**: Lee H. & Zhang R.
**摘要**: 利用商业化FOXC2抗体对临床乳腺癌组织样本进行染色，发现FOXC2高表达与患者预后不良显著相关，提示其可能作为三阴性乳腺癌的新型治疗靶点。
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3. **文献名称**: *FOXC2 Antibody Application in Lymphatic Development Studies*
**作者**: Garcia M. et al.
**摘要**: 通过FOXC2抗体在小鼠模型中的免疫荧光染色，揭示了FOXC2在胚胎淋巴管形态发生中的动态表达模式，证实其对淋巴内皮细胞分化的调控作用。
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(注：以上内容为模拟生成，实际文献需通过学术数据库检索。)
The FOXC2 antibody is a tool used to detect and study the FOXC2 protein, a member of the Forkhead box (FOX) family of transcription factors. FOXC2 plays critical roles in embryonic development, particularly in the formation of lymphatic vessels, mesenchymal cell differentiation, and lipid metabolism. It is also implicated in regulating epithelial-mesenchymal transition (EMT), a process linked to cancer metastasis and fibrosis. Mutations in the FOXC2 gene are associated with hereditary lymphedema-distichiasis syndrome, characterized by abnormal lymphatic system development and accessory eyelashes.
FOXC2 antibodies are widely utilized in research to investigate protein expression patterns, subcellular localization, and functional mechanisms in both normal and diseased tissues. They are essential in techniques like Western blotting, immunohistochemistry, and immunofluorescence. In cancer biology, FOXC2 antibodies help explore its role in tumor progression, drug resistance, and metastasis. However, antibody specificity and batch variability can pose challenges, necessitating validation using knockout controls or complementary assays.
The development of FOXC2 antibodies has advanced studies on metabolic disorders, lymphatic diseases, and cancer, offering insights into potential therapeutic targets. Despite progress, understanding FOXC2's complex regulatory networks and context-dependent functions remains an ongoing focus in biomedical research.
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