| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | FKHL17, FREAC9, FREAC-9 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human FOXD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FOXD2抗体的参考文献示例(部分信息为示例性，建议通过学术数据库验证准确性)：
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1. **文献名称**: *FOXD2 suppresses tumorigenesis in non-small cell lung cancer by regulating TGF-β signaling*
**作者**: Zhang, Y., et al.
**摘要**: 本研究利用FOXD2抗体进行免疫组化分析，发现FOXD2在肺癌组织中低表达，并通过抑制TGF-β通路抑制肿瘤转移。研究验证了该抗体的特异性，并确认FOXD2作为抑癌基因的潜在机制。
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2. **文献名称**: *FOXD2 regulates neural crest cell differentiation during embryonic development*
**作者**: Wang, L., et al.
**摘要**: 通过FOXD2抗体进行免疫荧光染色，揭示FOXD2在胚胎神经嵴细胞分化中的关键作用。研究结合敲除模型，证明FOXD2通过调控Wnt信号通路影响细胞命运决定。
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3. **文献名称**: *A novel monoclonal antibody targeting FOXD2 for glioblastoma diagnosis*
**作者**: Chen, H., et al.
**摘要**: 本文报道了一种高特异性抗FOXD2单克隆抗体的开发，并通过ELISA、Western blot验证其灵敏度。该抗体在胶质瘤组织诊断中显示出潜在临床应用价值。
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4. **文献名称**: *FOXD2-AS1 lncRNA promotes hepatocellular carcinoma progression via FOXD2 antibody-validated protein interactions*
**作者**: Li, X., et al.
**摘要**: 研究结合FOXD2抗体进行免疫沉淀(IP)，发现FOXD2-AS1长链非编码RNA通过结合FOXD2蛋白增强肝癌细胞侵袭能力，提示其作为治疗靶点的可能性。
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**备注**：以上文献信息为示例，实际引用时请通过PubMed、Web of Science等平台检索最新且经同行评审的论文，确保准确性。
The FOXD2 antibody is designed to target FOXD2. a member of the Forkhead box (FOX) family of transcription factors, which are characterized by a conserved DNA-binding domain known as the "forkhead box." FOXD2 plays critical roles in embryonic development, cellular differentiation, and tissue homeostasis. It regulates gene expression by binding to specific DNA sequences, influencing pathways involved in cell proliferation, apoptosis, and migration. Dysregulation of FOXD2 has been implicated in various cancers, including colorectal, breast, and ovarian cancers, where it may act as either an oncogene or tumor suppressor depending on the cellular context. For instance, FOXD2 overexpression has been linked to enhanced tumor invasiveness in certain malignancies, while its loss is associated with poor prognosis in others.
FOXD2 antibodies are essential tools for studying the protein's expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect FOXD2 in cell lines, tissues, or clinical samples. Validated antibodies help researchers explore FOXD2's role in disease mechanisms, its interaction partners, and its potential as a therapeutic target. Many commercially available FOXD2 antibodies are raised against specific epitopes within the protein and are tested for specificity using knockout controls or siRNA-mediated silencing. As research advances, FOXD2 antibodies continue to support investigations into developmental disorders, cancer biology, and regenerative medicine, highlighting their importance in both basic and translational studies.
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