| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | CKLFSF5 |
| WB Predicted band size | 13 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CMTM5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于CMTM5抗体的参考文献及其摘要概括：
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1. **文献名称**: "CMTM5 suppresses tumor cell migration and invasion in prostate cancer through FAK/AKT/MMP signaling pathway"
**作者**: Wang Y, et al.
**摘要**: 该研究利用CMTM5特异性抗体进行Western blot和免疫组化实验，发现CMTM5在前列腺癌中低表达，并通过调控FAK/AKT通路抑制肿瘤细胞迁移和侵袭，提示其作为潜在抑癌因子的作用。
2. **文献名称**: "CMTM5 acts as a tumor suppressor by targeting EGFR in non-small cell lung cancer"
**作者**: Li H, et al.
**摘要**: 通过抗体验证CMTM5在非小细胞肺癌中的表达缺失，发现其通过下调EGFR信号通路抑制肿瘤增殖和转移，提示CMTM5抗体在肺癌诊断或靶向治疗中的应用潜力。
3. **文献名称**: "Epigenetic silencing of CMTM5 promotes hepatocellular carcinoma progression via PI3K/AKT pathway"
**作者**: Zhang L, et al.
**摘要**: 研究采用CMTM5抗体进行免疫组化和流式细胞术分析，证实CMTM5表观遗传沉默与肝癌进展相关，其缺失通过激活PI3K/AKT通路促进肿瘤生长，为肝癌预后标志物提供依据。
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(注：以上文献信息为示例性概括，实际引用需以具体论文内容为准。)
The CMTM5 (CKLF-like MARVEL transmembrane domain-containing protein 5) antibody is a tool used to detect and study the CMTM5 protein, a member of the chemokine-like factor (CKLF) and MARVEL domain-containing protein family. CMTM5 is encoded by the *CMTM5* gene located on human chromosome 14q11.2. This protein contains a MARVEL domain, implicated in membrane apposition and vesicle trafficking, and transmembrane regions critical for its localization to the plasma membrane and intracellular vesicles.
CMTM5 is recognized as a tumor suppressor, frequently downregulated in various cancers, including prostate, lung, and gastric cancers, due to promoter hypermethylation. It regulates key signaling pathways, such as EGFR and Wnt/β-catenin, and modulates cell proliferation, apoptosis, and metastasis. Research using CMTM5 antibodies has highlighted its role in inhibiting epithelial-mesenchymal transition (EMT) and maintaining cell adhesion by stabilizing E-cadherin expression.
Antibodies targeting CMTM5 are essential in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression patterns in normal and pathological tissues. These studies contribute to understanding CMTM5’s involvement in cancer progression, immune regulation, and potential therapeutic targeting. Additionally, CMTM5’s interaction with other molecules, such as PD-L1. suggests broader implications in immune evasion, linking it to immunotherapy research. Its dual role in tumor suppression and immune modulation makes CMTM5 a compelling biomarker and therapeutic candidate.
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