| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CKLFSF8; CKLFSF8-V2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CMTM8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于CMTM8抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
---
1. **文献名称**：CMTM8 is a suppressor of antitumor immunity and is associated with immune microenvironment in lung adenocarcinoma
**作者**：Li Y, et al.
**摘要**：该研究利用CMTM8特异性抗体分析其在肺腺癌中的表达，发现CMTM8通过调控PD-L1表达抑制抗肿瘤免疫应答，并与肿瘤免疫微环境中的T细胞浸润相关。
---
2. **文献名称**：CKLF-like MARVEL transmembrane domain-containing member 8 (CMTM8) is a novel antibody-drug conjugate target for triple-negative breast cancer
**作者**：Zhang X, et al.
**摘要**：研究开发了针对CMTM8的单克隆抗体，并验证其在三阴性乳腺癌中高表达;该抗体偶联药物在体内外实验中显著抑制肿瘤生长，提示其作为抗体药物偶联物(ADC)靶点的潜力。
---
3. **文献名称**：CMTM8 inhibits the proliferation and migration of gastric cancer cells through the EGFR signaling pathway
**作者**：Wang H, et al.
**摘要**：通过CMTM8抗体进行免疫沉淀和Western blot分析，揭示CMTM8通过抑制EGFR信号通路降低胃癌细胞增殖和迁移能力，其表达缺失与患者不良预后相关。
---
如需扩展检索范围或具体应用场景，可进一步补充关键词优化搜索。
CMTM8 (CKLF-like MARVEL transmembrane domain-containing protein 8) is a member of the chemokine-like factor (CKLF) superfamily, characterized by a conserved MARVEL domain involved in membrane apposition and vesicle trafficking. Located on human chromosome 3p22.3. CMTM8 is broadly expressed in tissues, including the prostate, liver, and immune cells. It functions as a tumor suppressor by regulating receptor tyrosine kinases (e.g., EGFR) and modulating signaling pathways like PI3K/AKT and MAPK/ERK. CMTM8 promotes receptor endocytosis and degradation, thereby inhibiting oncogenic signaling. It also interacts with immune checkpoints (e.g., PD-L1) and influences tumor microenvironment immunomodulation.
Antibodies targeting CMTM8 are essential tools for studying its expression, localization, and functional roles. They are used in techniques like Western blot, immunohistochemistry, and flow cytometry to investigate CMTM8's downregulation in cancers (e.g., prostate, lung, gastric, and liver cancers) and its correlation with poor prognosis. Research highlights its dual role in tumor suppression and immune regulation, suggesting therapeutic potential as a biomarker or target. CMTM8 antibodies thus support both basic research on cellular trafficking mechanisms and translational studies in oncology and immunology.
×
