Rabbit Polyclonal GFRA3 Antibody

The GFRA3 (GDNF Family Receptor Alpha 3) antibody is a tool used to detect and study the GFRA3 protein, a member of the GDNF receptor family. GFRA3 is a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor that binds artemin, a ligand in the glial cell line-derived neurotrophic factor (GDNF) family. This receptor-ligand interaction activates the RET proto-oncogene tyrosine kinase, triggering downstream signaling pathways involved in neuronal survival, differentiation, and migration. GFRA3 is primarily expressed in peripheral and central nervous systems, playing roles in neural crest development, pain sensation, and neuropathic pain modulation. Dysregulation of GFRA3 has been implicated in neurodevelopmental disorders, neuropathic pain syndromes, and cancers, particularly those with RET pathway alterations. Researchers use GFRA3 antibodies in techniques like immunohistochemistry, Western blotting, and flow cytometry to investigate its expression patterns, cellular localization, and functional roles in disease models. These antibodies aid in elucidating mechanisms of neural circuit formation, nerve regeneration, and tumorigenesis, offering potential therapeutic insights for neurological and oncological conditions.