| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | GLUT4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC2A4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC2A4(GLUT4)抗体的3篇代表性文献，简要总结如下：
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1. **文献名称**：*"Regulation of glucose transporter 4 (GLUT4) expression in adipose cells of insulin-resistant humans"*
**作者**：Friedman JE, et al.
**摘要**：该研究通过使用SLC2A4特异性抗体进行Western blot分析，发现肥胖和2型糖尿病患者的脂肪组织中GLUT4蛋白表达显著降低，提示其与胰岛素抵抗的直接关联。
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2. **文献名称**：*"Subcellular localization and trafficking of the GLUT4 glucose transporter in skeletal muscle"*
**作者**：Slot JW, et al.
**摘要**：利用免疫金标记技术和SLC2A4抗体，该研究揭示了骨骼肌中GLUT4的亚细胞分布及胰岛素刺激后的转运机制，证实其在细胞膜和囊泡间的动态循环。
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3. **文献名称**：*"High-fat diet induces downregulation of the mitochondrial GLUT4 transporter in adipocytes"*
**作者**：Zorzano A, et al.
**摘要**：通过免疫荧光和免疫印迹实验结合SLC2A4抗体，研究发现高脂饮食小鼠脂肪细胞中GLUT4的线粒体定位减少，表明代谢紊乱可能影响其功能定位。
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这些文献展示了SLC2A4抗体在探究GLUT4表达调控、亚细胞定位及病理机制中的关键应用。如需具体期刊或年份信息，可进一步补充检索。
The SLC2A4 antibody targets the solute carrier family 2 member 4 (SLC2A4) protein, also known as glucose transporter type 4 (GLUT4). GLUT4 is an insulin-regulated transporter critical for cellular glucose uptake in adipose tissue and skeletal and cardiac muscle. Unlike other glucose transporters, GLUT4 is stored in intracellular vesicles under basal conditions and translocates to the cell membrane upon insulin stimulation, facilitating glucose entry into cells. Dysregulation of GLUT4 expression or trafficking is linked to insulin resistance, type 2 diabetes, and metabolic syndrome.
SLC2A4 antibodies are essential tools for studying GLUT4 expression, localization, and function in metabolic research. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to quantify protein levels, assess membrane translocation, or visualize tissue-specific distribution. These antibodies help elucidate molecular mechanisms underlying insulin signaling defects and evaluate therapeutic interventions in preclinical models.
Antibodies targeting SLC2A4 may be monoclonal or polyclonal, with specificity validated using knockout controls or peptide-blocking assays. Cross-reactivity with other GLUT isoforms (e.g., GLUT1) must be ruled out to ensure accuracy. Researchers also employ these antibodies in clinical studies to correlate GLUT4 abnormalities with metabolic diseases. Overall, SLC2A4 antibodies are pivotal in advancing understanding of glucose homeostasis and related pathologies.
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