| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | GLUR3, mGlu3, GPRC1C, MGLUR3 |
| WB Predicted band size | 99 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GRM3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GRM3抗体的3篇参考文献示例(注：内容为模拟概括，实际文献需通过数据库检索确认)：
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1. **文献名称**: *Targeting metabotropic glutamate receptor 3 for the treatment of glioblastoma*
**作者**: Smith A. et al.
**摘要**: 研究揭示了GRM3在胶质母细胞瘤中的异常激活，通过开发特异性GRM3抗体阻断下游mTOR通路，显著抑制肿瘤细胞增殖并增强化疗敏感性。
2. **文献名称**: *GRM3 antibodies as biomarkers in schizophrenia: a postmortem brain study*
**作者**: Johnson R.B. et al.
**摘要**: 利用高灵敏度GRM3抗体检测精神分裂症患者前额叶皮层的受体表达，发现GRM3水平降低与认知功能障碍相关，提示其作为病理标志物的潜力。
3. **文献名称**: *Development of a monoclonal anti-GRM3 antibody for synaptic localization studies*
**作者**: Lee C. & Zhang Y.
**摘要**: 报道了一种新型单克隆抗体的生成，通过免疫荧光和电镜技术证实其在啮齿类动物海马神经元中特异性标记GRM3.为突触可塑性研究提供工具。
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如需具体文献，建议通过PubMed或Google Scholar以“GRM3 antibody”或“anti-GRM3”为关键词检索，并筛选应用类或机制研究类论文。
The GRM3 antibody targets the metabotropic glutamate receptor 3 (mGluR3 or GRM3), a class C G protein-coupled receptor encoded by the GRM3 gene. Primarily expressed in the central nervous system (CNS), GRM3 regulates synaptic transmission and plasticity by modulating glutamate signaling, the primary excitatory neurotransmitter. It plays a role in neurodevelopment, cognition, and mood regulation, with dysregulation linked to neuropsychiatric disorders like schizophrenia, autism, and anxiety, as well as glioma progression.
GRM3 antibodies are essential tools for studying receptor localization, expression levels, and function in research. They are used in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry to investigate GRM3 distribution in brain tissues, cellular models, or tumor samples. These antibodies help elucidate GRM3's interaction with ligands, downstream signaling pathways (e.g., cAMP inhibition, MAPK activation), and its role in glutamate homeostasis.
Both monoclonal and polyclonal GRM3 antibodies are available, often validated for specificity via knockout controls or peptide-blocking assays. Challenges include ensuring minimal cross-reactivity with homologous receptors like GRM2 or GRM4. Commercially produced antibodies are widely used in preclinical studies to explore therapeutic strategies targeting GRM3 in neurological diseases and cancer.
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