| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3 |
| WB Predicted band size | 44 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PROKR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PROKR2抗体的参考文献示例(内容为模拟，仅供参考)：
1. **文献名称**: "Characterization of PROKR2 Antibody for Immunohistochemical Analysis in Hypothalamic Tissues"
**作者**: Smith A, et al.
**摘要**: 本研究验证了一种高特异性PROKR2抗体在啮齿动物下丘脑组织中的应用，证实其可用于定位PROKR2蛋白表达，揭示其在神经内分泌调节中的潜在作用。
2. **文献名称**: "PROKR2 Receptor Signaling in Reproductive Disorders: Insights from Antibody-Based Inhibition Studies"
**作者**: Lee J, et al.
**摘要**: 通过PROKR2抗体阻断实验，发现PROKR2信号通路异常可能导致促性腺激素分泌不足型性腺功能减退症(HH)，为生殖障碍的机制研究提供依据。
3. **文献名称**: "Development of a Novel Monoclonal Anti-PROKR2 Antibody for Western Blot and Flow Cytometry"
**作者**: Chen X, et al.
**摘要**: 该文献报道了一种新型单克隆PROKR2抗体的开发，验证了其在Western blot和流式细胞术中的高灵敏度和特异性，适用于体外细胞模型研究。
4. **文献名称**: "PROKR2 Expression in Human Tumors: A Comparative Study Using Immunohistochemistry"
**作者**: Garcia R, et al.
**摘要**: 通过PROKR2抗体对多种肿瘤组织进行免疫组化分析，发现PROKR2在胶质瘤和乳腺癌中高表达，提示其可能作为癌症治疗的潜在靶点。
**注意**：以上文献信息为模拟示例，实际引用请通过PubMed、Google Scholar等平台检索真实文献。
The PROKR2 antibody is a tool used to detect and study the prokineticin receptor 2 (PROKR2), a G protein-coupled receptor (GPCR) that binds prokineticin peptides (PROK1 and PROK2). PROKR2 plays critical roles in diverse physiological processes, including reproductive function, neurodevelopment, circadian rhythm regulation, and angiogenesis. It activates downstream signaling pathways, such as PKC and MAPK, influencing cell proliferation, migration, and differentiation. Mutations in the PROKR2 gene are linked to human disorders like hypogonadotropic hypogonadism (HH) and Kallmann syndrome (KS), characterized by delayed puberty and anosmia. Aberrant PROKR2 expression is also implicated in cancer progression, notably in glioblastoma and colorectal cancer.
PROKR2 antibodies, often polyclonal or monoclonal, are designed for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to analyze PROKR2 expression, localization, and regulation in tissues or cell lines. These antibodies aid in exploring PROKR2's role in disease mechanisms and normal physiology. Validation includes testing specificity via knockout controls or siRNA knockdown. Researchers use PROKR2 antibodies to investigate its interaction with ligands, receptor trafficking, and potential therapeutic targeting. Their development supports advancing diagnostics and treatments for PROKR2-related disorders, emphasizing their importance in both basic research and clinical contexts.
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