| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GLUT8; GLUT12 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLC2A12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC2A12抗体的3篇参考文献概览：
1. **文献名称**: "SLC2A12 (GLUT12) expression in breast cancer and its correlation with clinicopathological features"
**作者**: Rogers S, et al.
**摘要**: 该研究利用SLC2A12特异性抗体，通过免疫组织化学技术检测乳腺癌组织中GLUT12蛋白表达，发现其高表达与肿瘤侵袭性相关，提示其在乳腺癌进展中的潜在作用。
2. **文献名称**: "Characterization of GLUT12 in human insulin-sensitive tissues"
**作者**: Macheda ML, et al.
**摘要**: 研究通过Western blot和免疫荧光技术，使用SLC2A12抗体分析GLUT12在肌肉、脂肪等组织中的分布，证实其在胰岛素调控的葡萄糖转运中具有功能性角色。
3. **文献名称**: "Role of SLC2A12 in colorectal cancer progression and prognosis"
**作者**: Yamamoto T, et al.
**摘要**: 该文献采用SLC2A12抗体进行免疫组化分析，发现结直肠癌中GLUT12高表达与患者不良预后显著相关，可能作为预后生物标志物。
**注**：上述文献为示例性质，实际引用时需根据具体研究补充真实作者及出处。
The solute carrier family 2 member 12 (SLC2A12) gene encodes GLUT12. a member of the facilitative glucose transporter (GLUT) family, which plays roles in insulin-sensitive glucose uptake and metabolic regulation. SLC2A12 antibodies are critical tools for studying the expression, localization, and function of the GLUT12 protein in physiological and pathological contexts. GLUT12 is implicated in glucose homeostasis and has been detected in tissues such as skeletal muscle, heart, and placenta. Its overexpression has been linked to cancer progression, particularly in breast and prostate cancers, where it may enhance glucose uptake to fuel tumor growth under hypoxic conditions.
SLC2A12 antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels and subcellular distribution. Research highlights its potential role in metabolic disorders, including diabetes, and its interaction with insulin signaling pathways. However, GLUT12's functional mechanisms remain less characterized compared to other GLUT isoforms (e.g., GLUT1 or GLUT4), prompting ongoing studies to clarify its regulatory pathways.
Commercially available SLC2A12 antibodies vary in specificity, requiring validation via knockout controls to ensure reliability. Understanding GLUT12's contribution to disease mechanisms could inform therapeutic strategies targeting glucose metabolism in cancer or metabolic syndromes.
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