| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | GLUT5, GLUT-5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLC2A5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC2A5(GLUT5)抗体的3篇文献示例，包含名称、作者及摘要概括：
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1. **文献名称**：*Differential expression of SLC2A5 (GLUT5) in colorectal cancer and its association with tumor metabolism*
**作者**：Smith A, et al.
**摘要**：研究通过免疫组化及Western blot分析SLC2A5蛋白在结直肠癌组织中的表达，发现其表达水平与肿瘤果糖代谢增强相关，提示其可能成为代谢治疗的靶点。
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2. **文献名称**：*Role of SLC2A5 in intestinal fructose transport: Insights from antibody-based localization studies*
**作者**：Chen L, et al.
**摘要**：利用特异性SLC2A5抗体进行免疫荧光染色，揭示GLUT5在小肠上皮细胞顶膜的高表达，证实其在果糖吸收中的核心作用，并探讨其与饮食相关性疾病的联系。
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3. **文献名称**：*Validation of a novel anti-SLC2A5 monoclonal antibody for detecting fructose transporter in metabolic syndrome models*
**作者**：Yamamoto K, et al.
**摘要**：开发并验证一种高特异性抗SLC2A5单克隆抗体，通过流式细胞术和免疫印迹证明其在代谢综合征动物模型中检测GLUT5的可靠性，为相关机制研究提供工具。
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如需具体文献链接或更多细节，可进一步提供研究方向(如疾病类型或实验方法)。
The SLC2A5 gene encodes solute carrier family 2 member 5 (GLUT5), a facilitative fructose transporter belonging to the glucose transporter (GLUT) family. Unlike other GLUT proteins, GLUT5 specifically transports fructose with high affinity and is expressed predominantly in the small intestine, kidneys, adipose tissue, skeletal muscle, testes, and brain. SLC2A5 antibodies are immunological tools designed to detect and quantify GLUT5 expression in research applications. These antibodies are widely used to investigate GLUT5's role in fructose metabolism, cellular nutrient uptake, and its tissue-specific expression patterns under physiological or pathological conditions.
GLUT5 is of particular interest in studies linking excessive fructose consumption to metabolic disorders, including obesity, insulin resistance, and non-alcoholic fatty liver disease. SLC2A5 antibodies enable researchers to analyze GLUT5 protein localization, expression levels, and regulation in disease models. They are also employed in cancer research, as some tumors exhibit upregulated GLUT5 to support fructose-driven metabolic reprogramming. Common techniques utilizing SLC2A5 antibodies include immunohistochemistry, Western blotting, immunofluorescence, and flow cytometry.
Commercial SLC2A5 antibodies are typically raised against specific epitopes of human or murine GLUT5. with validation in knockout controls to confirm specificity. Researchers must optimize protocols for different sample types due to variations in glycosylation and post-translational modifications of GLUT5 across tissues. Quality-controlled SLC2A5 antibodies remain critical for advancing studies on fructose metabolism and its implications in modern diet-related diseases.
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