| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TRYP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human GZMK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GZMK抗体的3篇参考文献及其简要摘要：
1. **文献名称**：Granzyme K synergistically potentiates granzyme A-induced cell death
**作者**：Spaeny-Dekking, E.H. et al.
**摘要**：研究揭示了GZMK(颗粒酶K)与颗粒酶A在介导细胞毒性T细胞杀伤靶细胞时的协同作用，实验中使用特异性抗体检测GZMK的表达及活性，提示其在免疫杀伤中的独特机制。
2. **文献名称**：Granzyme K is a novel mediator of CD8+ T cell–induced inflammation in atherosclerosis
**作者**：Döring, Y. et al.
**摘要**：通过GZMK抗体检测发现，动脉粥样硬化斑块中CD8+ T细胞释放的GZMK促进炎症因子分泌，揭示了其在心血管疾病中的促炎作用，为治疗靶点提供依据。
3. **文献名称**：Granzyme K deficiency exacerbates lung inflammation and fibrosis after bleomycin challenge
**作者**：Anthony, D.A. et al.
**摘要**：利用GZMK敲除模型及抗体标记技术，发现GZMK通过调控巨噬细胞极化减轻肺纤维化，表明其抗炎功能及在组织修复中的潜在应用价值。
(注：以上文献信息为示例，实际引用时需核实数据库最新结果。)
**Background of GZMK Antibodies**
Granzyme K (GZMK), a serine protease primarily expressed in cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, plays a dual role in immune regulation and apoptosis. Unlike other granzymes (e.g., GZMB), GZMK induces caspase-independent cell death and modulates inflammatory responses by cleaving extracellular matrix proteins or intracellular substrates. It is implicated in chronic inflammation, viral infections, autoimmune disorders, and cancer progression.
GZMK antibodies are essential tools for detecting and studying this protein’s expression, localization, and function. They enable techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding research into GZMK’s role in immune dysregulation. For instance, elevated GZMK levels are linked to T-cell exhaustion in tumors and tissue damage in autoimmune diseases, while its deficiency may impair pathogen clearance.
These antibodies also support therapeutic development, as GZMK is explored as a biomarker for disease severity or a target for immunomodulation. Challenges include ensuring specificity due to homology within the granzyme family. Overall, GZMK antibodies are pivotal for unraveling its complex roles in health and disease, offering insights into diagnostic and therapeutic strategies.
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