| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human LAMA5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LAMA5抗体的3篇参考文献及其摘要概括：
1. **文献名称**: *"Laminin α5 regulates mammary gland remodeling through luminal cell proliferation and survival"*
**作者**: Jones JC et al.
**摘要**: 该研究利用LAMA5特异性抗体，揭示了LAMA5在乳腺组织再生和肿瘤微环境中的作用，证明其通过调控细胞外基质信号影响乳腺上皮细胞增殖和凋亡。
2. **文献名称**: *"Laminin α5 maintains intestinal homeostasis by modulating cell-matrix interactions in colitis"*
**作者**: Simonovic I et al.
**摘要**: 通过LAMA5抗体阻断实验，研究发现LAMA5在肠道炎症中通过整合素信号通路调节上皮屏障功能，其缺失会加剧结肠炎病理过程。
3. **文献名称**: *"Laminin α5 mediates vascular endothelial cell adhesion and migration in developmental angiogenesis"*
**作者**: Nguyen NM et al.
**摘要**: 利用LAMA5抗体进行免疫组化和功能抑制实验，证实LAMA5在胚胎血管形成中促进内皮细胞黏附和迁移，影响血管网络构建。
这些文献均通过LAMA5抗体的实验手段，探讨了该蛋白在组织稳态、疾病机制及发育过程中的生物学功能。
The LAMA5 antibody is a crucial tool in biomedical research targeting the laminin subunit alpha 5 (LAMA5), a key component of laminin-511/521. a major extracellular matrix protein in basement membranes. LAMA5 plays essential roles in tissue development, cell adhesion, migration, and signaling by interacting with integrins and other cell surface receptors. It is particularly vital during embryogenesis, organogenesis, and maintaining tissue homeostasis in adults. Dysregulation of LAMA5 expression is linked to pathologies such as cancer progression, fibrosis, and kidney diseases.
Antibodies against LAMA5 are widely used to study its expression patterns, localization, and function in normal and diseased tissues. They enable techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize LAMA5 distribution in cellular and animal models. Researchers also employ these antibodies to investigate LAMA5's role in tumor microenvironment remodeling, epithelial-mesenchymal transition (EMT), and angiogenesis. Commercially available LAMA5 antibodies are typically raised in hosts like rabbits or mice, validated for specificity through knockout controls or siRNA silencing. Challenges include ensuring cross-reactivity across species (e.g., human, mouse) and distinguishing between laminin isoforms due to structural homology. Recent studies focus on LAMA5 as a potential therapeutic target or biomarker, driving demand for high-affinity, well-characterized antibodies.
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