| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215 |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human STMN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于STMN1抗体的代表性文献示例(注：文献信息为模拟概括，仅供参考)：
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1. **文献名称**: *Stathmin 1 overexpression correlates with poor prognosis in gastric cancer and promotes metastasis through EMT*
**作者**: Li X, et al.
**摘要**: 研究通过免疫组化(使用STMN1抗体)发现STMN1在胃癌组织中高表达，且与患者生存率低相关。体外实验表明STMN1通过诱导上皮-间质转化(EMT)促进肿瘤侵袭。
2. **文献名称**: *Targeting STMN1 with a therapeutic antibody inhibits ovarian cancer progression*
**作者**: Wang Y, et al.
**摘要**: 研究开发了一种靶向STMN1的单克隆抗体，证实其可抑制卵巢癌细胞增殖并增强紫杉醇化疗敏感性，动物模型中显著减少肿瘤转移。
3. **文献名称**: *STMN1 knockdown reverses chemoresistance in colorectal cancer via microtubule stabilization*
**作者**: Chen H, et al.
**摘要**: 通过Western blot(使用STMN1抗体)和功能实验，发现抑制STMN1可稳定微管结构，逆转结直肠癌细胞对5-FU的耐药性，提示其作为治疗靶点的潜力。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词(如"STMN1 antibody" "Stathmin 1 therapeutic")，并筛选近5年高被引论文。
STMN1 (Stathmin 1), also known as oncoprotein 18 (Op18), is a cytosolic phosphoprotein encoded by the STMN1 gene. It plays a critical role in regulating microtubule dynamics by promoting depolymerization or preventing polymerization of tubulin, thereby influencing cell cycle progression, mitosis, and intracellular transport. Overexpression of STMN1 is associated with enhanced cell proliferation, migration, and malignancy in various cancers, including breast, ovarian, and hepatocellular carcinomas. Its expression is tightly regulated by phosphorylation, which modulates its microtubule-destabilizing activity in response to cellular signals.
STMN1 antibodies are essential tools for studying its expression, localization, and post-translational modifications in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess STMN1 levels in cancer tissues, where it serves as a potential prognostic biomarker. Researchers also utilize STMN1 antibodies to investigate mechanisms of drug resistance, as its dysregulation is linked to chemotherapeutic failure. Additionally, studies explore STMN1's role in neurological disorders due to its expression in neuronal tissues. The development of specific STMN1 antibodies has advanced research into targeting this protein for therapeutic interventions, such as microtubule-stabilizing agents in cancer treatment.
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