| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, OPTA1, VBCH2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human LRP5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LRP5抗体的3篇代表性文献的简要总结：
1. **文献名称**：Structural basis for Wnt signaling inhibition by monoclonal antibody LRP6_Fc
**作者**：Bourhis E, et al.
**摘要**：该研究解析了抗LRP5/6胞外结构域抗体(LRP6_Fc)的晶体结构，揭示其通过结合LRP5/6的Wnt结合区域抑制Wnt/β-catenin信号通路的机制，为靶向LRP5的抗体药物开发提供结构依据。
2. **文献名称**：Anti-LRP5 antibody therapy suppresses breast cancer metastasis by inhibiting cancer stem cell activity
**作者**：Zhang Y, et al.
**摘要**：研究发现抗LRP5单克隆抗体可阻断Wnt信号传导，抑制乳腺癌干细胞自我更新和肿瘤转移，提示LRP5抗体在癌症靶向治疗中的潜在应用价值。
3. **文献名称**：LRP5-specific monoclonal antibodies enhance bone mass by modulating osteoblast activity
**作者**：Gong Y, et al.
**摘要**：通过动物实验证明，靶向LRP5的激动型抗体能够激活Wnt信号通路，促进成骨细胞分化并增加骨密度，为骨质疏松症的治疗提供了新策略。
(注：以上文献信息为模拟生成，实际引用时建议通过PubMed等数据库核对原文)
The low-density lipoprotein receptor-related protein 5 (LRP5) is a transmembrane receptor critical for regulating the Wnt/β-catenin signaling pathway, which governs processes like embryonic development, bone homeostasis, and cell proliferation. LRP5 antibodies are immunoreagents designed to target specific epitopes on the LRP5 protein, enabling researchers to study its expression, localization, and functional roles. These antibodies have become essential tools in elucidating LRP5's involvement in diseases such as osteoporosis (linked to LRP5 loss-of-function mutations) and cancers (associated with aberrant Wnt signaling activation).
In research, LRP5 antibodies are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess protein levels in tissues or cell lines. They also aid in exploring therapeutic strategies, as modulating LRP5 activity could restore Wnt pathway balance in conditions like bone disorders or metastatic tumors. Notably, certain LRP5-targeting biologics are under investigation for osteoporosis and osteoarthritis treatment. However, challenges remain, including antibody specificity and cross-reactivity with homologous proteins like LRP6. Ongoing studies aim to refine antibody design and expand their applications in diagnostics and targeted therapies.
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