| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | LAMA, S-LAM-alpha |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human LAMA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LAMA1抗体的3篇参考文献示例(内容为虚构，供参考格式)：
1. **标题**：*LAMA1 Antibody Reveals Critical Role in Neural Crest Cell Migration*
**作者**：Smith, J.R., et al.
**摘要**：本研究利用LAMA1特异性抗体，通过免疫组化和Western blot分析，揭示了LAMA1在小鼠胚胎神经嵴细胞迁移中的关键作用。结果显示，LAMA1缺失导致细胞外基质黏附异常，提示其与先天性神经系统发育障碍相关。
2. **标题**：*LAMA1 Expression in Cancer: Insights from Immunohistochemical Staining*
**作者**：Chen, L., & Tanaka, M.
**摘要**：通过LAMA1抗体对多种癌症组织样本进行染色，发现LAMA1在转移性肿瘤中表达显著下调。该研究提出LAMA1可能作为抑制上皮-间质转化(EMT)的潜在标志物，为癌症治疗提供新靶点。
3. **标题**：*LAMA1 Antibody-Based Validation of a Novel Knockout Mouse Model*
**作者**：Gomez, S., et al.
**摘要**：研究利用LAMA1抗体验证了基因编辑小鼠模型中LAMA1的完全缺失，并发现该模型表现出视网膜发育缺陷和肌肉纤维化，进一步支持LAMA1在组织稳态中的重要性。
(注：以上文献为示例，实际引用需根据具体研究检索PubMed、Google Scholar等数据库。)
The LAMA1 antibody targets the laminin subunit alpha-1 (LAMA1), a critical component of laminin-111. a glycoprotein in the extracellular matrix (ECM). Laminins are heterotrimeric proteins composed of α, β, and γ chains, playing essential roles in cell adhesion, differentiation, and tissue organization. LAMA1. encoded by the *LAMA1* gene, is predominantly expressed in basement membranes during embryonic development and tissue homeostasis. It contributes to structural integrity and cellular signaling by interacting with integrins and other ECM receptors.
LAMA1 antibodies are widely used in research to study tissue morphogenesis, neural development, and diseases linked to ECM dysfunction. Mutations in *LAMA1* are associated with Poretti-Boltshauser syndrome, a rare genetic disorder characterized by brain malformations and retinal defects. In cancer, altered LAMA1 expression has been implicated in tumor progression and metastasis, making it a potential biomarker.
These antibodies are typically produced in hosts like rabbits or mice, using immunogenic peptides derived from LAMA1's conserved regions. They enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Validation includes knockout controls and tissue-specific expression patterns to ensure specificity. Commercial LAMA1 antibodies are vital tools for exploring ECM biology, developmental pathways, and therapeutic targets in ECM-related pathologies.
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