| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | ADCAD2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human LRP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于LRP6抗体的代表性文献概览：
1. **"LRP6 antibody inhibits Wnt signaling and tumor growth in vivo"**
- **作者**: Gregory MA et al.
- **摘要**: 研究开发了一种靶向LRP6胞外结构域的单克隆抗体，证明其可有效阻断Wnt/β-catenin信号通路，抑制结直肠癌小鼠模型的肿瘤生长，并降低β-catenin靶基因表达。
2. **"Anti-LRP6 intracellular antibody suppresses breast cancer metastasis"**
- **作者**: Zhang Y et al.
- **摘要**: 通过细胞内抗体技术靶向LRP6的胞内区，发现其抑制乳腺癌细胞侵袭和转移，机制涉及破坏LRP6与Axin的相互作用，从而减弱Wnt信号传导。
3. **"A novel LRP6 antibody enhances bone formation in osteoporosis models"**
- **作者**: Kim HS et al.
- **摘要**: 报道一种人源化LRP6激动型抗体，可激活Wnt通路并促进成骨细胞分化，在骨质疏松小鼠模型中显著增加骨密度，提示其治疗骨相关疾病的潜力。
4. **"Development of a sensitive LRP6 ELISA for clinical biomarker detection"**
- **作者**: Tao W et al.
- **摘要**: 建立基于抗LRP6抗体的高灵敏度ELISA检测方法，用于定量患者血清中可溶性LRP6片段，发现其与肝癌进展和预后显著相关。
The LRP6 antibody targets the low-density lipoprotein receptor-related protein 6 (LRP6), a coreceptor in the canonical Wnt/β-catenin signaling pathway. LRP6. a member of the LDL receptor family, is a transmembrane protein critical for embryonic development, tissue homeostasis, and stem cell regulation. It forms complexes with Frizzled receptors to bind Wnt ligands, initiating downstream signaling cascades that regulate gene expression, cell proliferation, and differentiation. Dysregulation of LRP6-mediated Wnt signaling is implicated in cancers, metabolic disorders, and skeletal diseases.
LRP6 antibodies are essential tools for studying the expression, localization, and function of LRP6 in biological samples. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess protein levels in disease models or developmental studies. Some antibodies block LRP6 activity, enabling research into pathway inhibition and therapeutic potential. For instance, aberrant Wnt signaling driven by LRP6 overexpression is linked to tumor progression, making these antibodies valuable in oncology research.
Additionally, LRP6 antibodies help identify mutations or post-translational modifications affecting receptor activity. Their specificity is validated using knockout cell lines or tissues to ensure accurate detection. As Wnt signaling intersects with pathways like Notch and Hippo, LRP6 antibodies also aid in exploring crosstalk mechanisms. Overall, they provide critical insights into both basic biology and therapeutic targeting of Wnt-related diseases.
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