| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MC2 |
| WB Predicted band size | 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human MC5R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MC5R抗体的假设性参考文献示例(实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*Development and Characterization of a Novel Monoclonal Antibody for Melanocortin 5 Receptor (MC5R)*
**作者**：Smith A, et al.
**摘要**：本研究报道了一种新型抗MC5R单克隆抗体的开发，通过免疫印迹和免疫组化验证其特异性，可用于检测多种哺乳动物组织中的MC5R蛋白表达，为MC5R功能研究提供工具。
2. **文献名称**：*MC5R Expression in Adipose Tissue: Insights from Immunohistochemical Analysis*
**作者**：Lee B, et al.
**摘要**：利用特异性MC5R抗体探究MC5R在脂肪组织中的分布，发现其与脂代谢相关信号通路关联，提示MC5R可能在肥胖调控中发挥作用。
3. **文献名称**：*Cross-Reactivity of Anti-MC5R Antibodies Across Species: Implications for Translational Research*
**作者**：Garcia R, et al.
**摘要**：评估了多种MC5R抗体在小鼠、大鼠和人类样本中的交叉反应性，发现部分抗体存在物种特异性差异，强调抗体选择对跨物种研究的重要性。
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**注意**：以上为示例性内容，实际文献需通过PubMed、Web of Science等平台检索。建议用户结合关键词“MC5R antibody”“melanocortin receptor 5 antibody”进行精准查询。
The melanocortin-5 receptor (MC5R) is a G protein-coupled receptor (GPCR) that belongs to the melanocortin receptor family, which includes five subtypes (MC1R-MC5R). MC5R is primarily activated by α-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH), signaling through cAMP-PKA pathways. It is widely expressed in peripheral tissues, including adipose tissue, exocrine glands, immune cells, and the central nervous system. MC5R plays roles in energy homeostasis, lipid metabolism, immune regulation, and exocrine secretion, though its functions are less characterized compared to other melanocortin receptors like MC4R (linked to obesity).
MC5R antibodies are immunological tools developed to study the receptor's expression, localization, and signaling mechanisms. These antibodies are typically raised in hosts like rabbits or mice using peptide antigens derived from MC5R's extracellular or intracellular domains. Validation involves Western blotting, immunohistochemistry, and knockout controls to ensure specificity. Applications include investigating MC5R's involvement in metabolic disorders, inflammatory responses, and sebum production. Challenges in antibody development arise from MC5R's structural homology with other melanocortin receptors and low endogenous expression levels. Recent studies using MC5R antibodies have highlighted its potential as a therapeutic target for diseases like metabolic syndrome and dermatitis.
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