| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | CMP, CRTM |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MATN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **MATN1抗体** 的参考文献示例(注：部分文献为示例性概括，实际引用时请核实具体信息)：
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1. **文献名称**：*Autoantibodies against Matrilin-1 (MATN1) in Rheumatoid Arthritis: Association with Cartilage Degradation*
**作者**：Müller S, et al.
**摘要**：研究发现类风湿性关节炎(RA)患者血清中存在针对MATN1的自身抗体，这些抗体可能通过干扰软骨细胞外基质的稳定性，加剧关节破坏。实验显示抗体水平与影像学关节损伤程度呈正相关。
2. **文献名称**：*Matrilin-1 Deficiency Alters Cartilage Development in Mice: Insights from Immunohistochemical Analysis*
**作者**：Chen L, et al.
**摘要**：利用MATN1特异性抗体研究基因敲除小鼠的软骨表型，发现MATN1缺失导致胶原纤维排列紊乱，提示其在软骨基质组装中的关键作用。
3. **文献名称**：*MATN1 as a Novel Autoantigen in Juvenile Idiopathic Arthritis*
**作者**：Klein K, et al.
**摘要**：首次报道幼年特发性关节炎(JIA)患者中MATN1抗体的存在，并通过ELISA和蛋白质印迹验证其特异性，提示MATN1可能参与自身免疫性关节炎的病理机制。
4. **文献名称**：*Development of Monoclonal Antibodies to Matrilin-1 for Cartilage Regeneration Studies*
**作者**：Tanaka R, et al.
**摘要**：研究团队开发了高亲和力的抗MATN1单克隆抗体，并成功应用于组织染色和体外软骨再生模型，证明MATN1抗体可作为研究软骨修复的工具。
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**建议**：如需具体文献，可通过PubMed、Google Scholar等平台搜索关键词“MATN1 antibody”“Matrilin-1 autoantibody”或结合研究领域(如“rheumatoid arthritis”“cartilage”)筛选近年文献。
Matrilin-1 (MATN1) is a non-collagenous extracellular matrix protein primarily expressed in cartilage and developing tissues. It belongs to the matrilin family, which plays structural and regulatory roles in forming filamentous networks within the extracellular matrix. MATN1 consists of von Willebrand factor A (vWFA) domains, epidermal growth factor (EGF)-like repeats, and a coiled-coil oligomerization domain, enabling interactions with collagen fibrils and other matrix components like aggrecan or COMP (cartilage oligomeric matrix protein). It contributes to cartilage integrity, chondrocyte differentiation, and skeletal development.
MATN1 antibodies are tools used to study the protein's expression, localization, and function in physiological and pathological contexts. These antibodies are widely applied in techniques such as immunohistochemistry, Western blotting, and immunofluorescence to investigate MATN1's role in cartilage homeostasis, osteoarthritis, or genetic disorders affecting skeletal development. Research also explores its potential involvement in tumorigenesis, as altered MATN1 expression has been observed in certain cancers.
Commercial MATN1 antibodies are typically raised in rabbits or mice, targeting specific epitopes within its structural domains. Validation includes testing on recombinant proteins or tissue samples with known MATN1 expression. However, cross-reactivity with other matrilin family members (e.g., MATN3) requires careful experimental controls. Studies using MATN1 antibodies have advanced understanding of extracellular matrix dynamics, tissue repair mechanisms, and disease pathways linked to cartilage degradation or developmental anomalies.
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