| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | LSFC, GP130, LRP130, CLONE-23970 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human LRPPRC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于LRPPRC抗体的参考文献摘要示例(注：文献标题和作者为虚构示例，仅供格式参考)：
1. **标题**: *LRPPRC regulates mitochondrial RNA stability and translation*
**作者**: Sasarman F, et al.
**摘要**: 研究利用LRPPRC特异性抗体，发现该蛋白通过结合线粒体mRNA维持其稳定性，并调控呼吸链复合物的翻译效率，突变导致线粒体脑肌病。
2. **标题**: *LRPPRC interacts with Wnt signaling pathway in colorectal cancer*
**作者**: Cooper TJ, et al.
**摘要**: 通过免疫共沉淀(使用LRPPRC抗体)发现LRPPRC与β-catenin相互作用，促进结直肠癌中Wnt通路激活，影响肿瘤增殖和转移。
3. **标题**: *LRPPRC promotes hepatocellular carcinoma progression via HIF-1α-mediated glycolysis*
**作者**: Liu Y, et al.
**摘要**: 研究使用LRPPRC抗体进行免疫组化分析，显示LRPPRC在肝癌中高表达，通过稳定HIF-1α增强糖酵解，促进肿瘤生长和耐药。
如需真实文献，建议通过PubMed或Google Scholar检索“LRPPRC antibody”或“LRPPRC function”获取具体研究。
The LRPPRC (Leucine-Rich Pentatricopeptide Repeat Containing) protein is a critical mitochondrial protein involved in RNA processing, stabilization, and translation. It plays a key role in maintaining mitochondrial mRNA stability and coordinating the assembly of mitochondrial ribosomes. Mutations in the LRPPRC gene are linked to Leigh syndrome French Canadian type (LSFC), a severe neurological disorder characterized by impaired mitochondrial energy production.
LRPPRC antibodies are essential tools for studying mitochondrial gene regulation and disease mechanisms. These antibodies enable detection and localization of LRPPRC in tissues or cultured cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use them to investigate LRPPRC's interaction with SLIRP (a stabilizing partner) and its role in post-transcriptional regulation of mitochondrial transcripts.
Studies utilizing LRPPRC antibodies have revealed its tissue-specific expression patterns and reduced levels in LSFC patients, correlating with respiratory chain deficiencies. Such findings underscore its importance in mitochondrial metabolism and pathophysiology. Additionally, these antibodies aid in exploring LRPPRC's emerging roles beyond mitochondria, including potential involvement in cancer progression and cellular stress responses. The development of high-specificity LRPPRC antibodies continues to advance research into mitochondrial disorders and therapeutic strategies.
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