| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human LRP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LRP3抗体的3篇参考文献的简要概括(注：文献信息为示例性内容，实际文献需通过学术数据库验证)：
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1. **文献名称**：*LRP3 modulates Wnt/β-catenin signaling by regulating cell-surface expression of Frizzled receptors*
**作者**：Smith A, et al.
**摘要**：研究利用抗LRP3抗体探究其在Wnt信号通路中的作用，发现LRP3通过调控Frizzled受体膜定位影响β-catenin活性，提示其在胚胎发育和癌症中的潜在功能。
2. **文献名称**：*LRP3 antibody-based targeting inhibits tumor growth in a xenograft model*
**作者**：Chen L, et al.
**摘要**：开发了一种人源化LRP3单克隆抗体，体外实验显示其可阻断LRP3与配体结合，并在小鼠模型中显著抑制肿瘤增殖，表明其作为癌症治疗药物的潜力。
3. **文献名称**：*Tissue-specific expression profiling of LRP3 using a novel monoclonal antibody*
**作者**：Yamamoto K, et al.
**摘要**：报道了一种高特异性抗LRP3抗体的开发，并通过免疫组化揭示LRP3在肝脏和神经组织中的高表达，为研究其生理功能提供了工具。
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**建议**：可通过PubMed或Google Scholar搜索**"LRP3 antibody"**或**"LRP3 function"**获取具体文献(例如PMID或DOI标识)。部分真实研究可能涉及LRP3在代谢、神经疾病或癌症中的作用。
**Background of LRP3 Antibody**
The low-density lipoprotein receptor-related protein 3 (LRP3) is a member of the LDL receptor family, which plays diverse roles in cellular processes such as endocytosis, signal transduction, and lipid metabolism. LRP3. encoded by the *LRP3* gene, is a transmembrane protein characterized by ligand-binding domains, epidermal growth factor (EGF) repeats, and a cytoplasmic tail involved in intracellular signaling. While less studied compared to other family members (e.g., LRP1 or LRP2), LRP3 has been implicated in regulating pathways like Wnt/β-catenin signaling, cellular cholesterol homeostasis, and receptor-mediated endocytosis.
LRP3 antibodies are essential tools for studying the protein's expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect LRP3 in tissues or cultured cells. Research suggests LRP3 may influence diseases such as cancer, where altered expression correlates with tumor progression, or metabolic disorders linked to lipid dysregulation. However, its precise physiological and pathological roles remain under investigation.
Commercially available LRP3 antibodies are typically developed against specific epitopes (e.g., extracellular or intracellular domains) and validated for species reactivity (e.g., human, mouse). Their applications extend to mechanistic studies, biomarker discovery, and therapeutic target validation, highlighting LRP3's emerging significance in biomedical research.
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