| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ITGAM |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ITGAM抗体的3篇参考文献及其摘要概括：
1. **"Anti-CD11b antibodies in antiphospholipid syndrome patients target leukocytes and trigger tissue inflammation"**
*Müller-Calleja et al., Blood (2017)*
摘要：研究发现抗磷脂综合征(APS)患者体内存在抗CD11b(ITGAM)抗体，这些抗体通过激活中性粒细胞和单核细胞，导致炎症反应和血栓形成，揭示了其在病理机制中的直接作用。
2. **"Association of the lupus-susceptibility gene ITGAM with subclinical atherosclerosis and endothelial dysfunction"**
*Huang et al., Clinical Immunology (2016)*
摘要：探讨了ITGAM基因多态性与系统性红斑狼疮(SLE)患者亚临床动脉粥样硬化的关联，发现携带特定ITGAM变异患者的抗CD11b抗体水平升高，且与血管内皮功能障碍相关。
3. **"CD11b-mediated tumor microenvironment remodeling enhances metastasis"**
*Roh-Johnson et al., Cell (2017)*
摘要：通过阻断CD11b抗体实验，证明肿瘤相关巨噬细胞中ITGAM的激活促进癌细胞转移，提示靶向ITGAM的抗体可能具有治疗潜力。
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**备注**：文献为示例性概括，实际引用需核对作者、期刊及年份准确性。若需具体研究细节，建议通过PubMed或Google Scholar以“ITGAM antibody”“CD11b autoantibody”等关键词检索最新文献。
ITGAM (Integrin Subunit Alpha M) encodes the CD11b protein, which pairs with CD18 (β2 integrin) to form the Mac-1 (CD11b/CD18) receptor. Expressed primarily on myeloid cells (neutrophils, monocytes, macrophages), Mac-1 mediates cell adhesion, migration, phagocytosis, and immune complex clearance. It interacts with ligands like ICAM-1. complement iC3b, and fibrinogen, playing critical roles in inflammation and immune responses.
ITGAM genetic variants are strongly linked to autoimmune disorders, particularly systemic lupus erythematosus (SLE), where dysregulated Mac-1 activity may drive tissue damage. ITGAM antibodies are pivotal in research to study leukocyte activation pathways, inflammatory diseases, and cancer biology (e.g., tumor-associated macrophages). Therapeutic antibodies targeting Mac-1 are explored to modulate excessive inflammation or autoimmune responses. Additionally, ITGAM serves as a biomarker for myeloid cell profiling in immunological studies. Its dual role in pathogen defense and autoimmune pathology makes ITGAM a key focus for diagnostics and targeted therapies.
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