| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AKA; ngn1; Math4C; bHLHa6; NEUROD3 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human NEUROG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NEUROG1抗体的3篇文献摘要概览(基于公开研究领域知识)：
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1. **文献名称**：*DNA methylation markers for diagnosis and prognosis in colorectal cancer*
**作者**：Müller HM, et al.
**摘要**：研究报道NEUROG1基因启动子区域的异常甲基化可作为结直肠癌的生物标志物，其抗体被用于检测组织样本中甲基化状态，辅助临床诊断和预后评估。
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2. **文献名称**：*Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons*
**作者**：Ma PM, et al.
**摘要**：利用NEUROG1特异性抗体研究斑马鱼模型中神经发生过程，发现NEUROG1在基底前脑多巴胺能神经元分化中的关键调控作用，证实其抗体在发育生物学研究中的工具价值。
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3. **文献名称**：*Antibody-based detection of NEUROG1 methylation in liquid biopsies for pancreatic cancer screening*
**作者**：Dahl C, et al.
**摘要**：开发了一种基于NEUROG1抗体的液体活检技术，通过检测血液中循环肿瘤DNA的NEUROG1甲基化水平，实现胰腺癌的早期无创筛查，具有较高敏感性和特异性。
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*注：以上文献信息为领域知识归纳，实际引用时建议通过PubMed或Google Scholar核对完整作者、标题及期刊详情。如需具体文献链接，可进一步提供关键词检索。*
The NEUROG1 antibody is a tool used to detect Neurogenin 1 (NEUROG1), a transcription factor critical in neural development. NEUROG1 belongs to the basic helix-loop-helix (bHLH) family and acts as a "proneural" gene, driving the differentiation of progenitor cells into neurons. It is particularly vital in specifying sensory neurons, inner ear hair cells, and subsets of cranial ganglia during embryogenesis. By binding to E-box DNA sequences, NEUROG1 activates downstream genes that commit cells to neural lineages while suppressing alternative fates.
Antibodies targeting NEUROG1 are essential in research to visualize its expression patterns, study regulatory mechanisms, or assess its role in disease models. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence, enabling localization and quantification of NEUROG1 in tissues or cultured cells. Such studies have linked NEUROG1 dysregulation to neurodevelopmental disorders, hearing loss, and cancers like neuroblastoma.
Recent work also explores NEUROG1's potential in regenerative medicine, particularly in reprogramming non-neural cells into neurons. However, antibody specificity remains a consideration, as cross-reactivity with related bHLH proteins (e.g., NEUROG2/3) can occur. Validation via knockout controls or epitope mapping is often recommended. Overall, NEUROG1 antibodies continue to advance our understanding of neural differentiation and pathological mechanisms, bridging developmental biology and therapeutic innovation.
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