| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | EL3; HS2; SPH2; HSPTB1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SPTB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC8A3抗体的3篇参考文献示例(注：文献为虚构示例，仅用于格式参考)：
1. **文献名称**：*"SLC8A3 Antibody Characterization in Sperm Calcium Homeostasis"*
**作者**：Smith J, et al.
**摘要**：本研究通过免疫印迹和免疫荧光验证了SLC8A3抗体的特异性，发现SLC8A3在哺乳动物精子尾部高表达，调控钙离子外流，影响精子运动能力。
2. **文献名称**：*"Role of SLC8A3 in Skeletal Muscle Calcium Signaling"*
**作者**：Lee H, et al.
**摘要**：利用SLC8A3抗体进行组织定位分析，揭示其在骨骼肌T管系统中的分布，表明其通过调节局部钙浓度影响肌肉收缩功能。
3. **文献名称**：*"SLC8A3 Expression in Retinal Neurons: Antibody Validation and Functional Implications"*
**作者**：Garcia R, et al.
**摘要**：通过敲除模型验证抗体特异性，发现SLC8A3在视网膜双极细胞中高表达，参与视觉信号传递中的钙离子清除。
如需真实文献，建议通过PubMed或Google Scholar检索关键词：*SLC8A3 antibody validation* 或 *SLC8A3 sodium-calcium exchanger*。
The SLC8A3 antibody targets the solute carrier family 8 member 3 (SLC8A3), also known as the sodium-calcium exchanger 3 (NCX3), a transmembrane protein critical for maintaining cellular calcium homeostasis. NCX3 facilitates the bidirectional exchange of Na⁺ and Ca²⁺ across the plasma membrane, depending on ion gradients and membrane potential. It plays a vital role in regulating intracellular calcium levels, particularly in excitable tissues such as neurons, skeletal muscle, and cardiac cells. Dysregulation of NCX3 has been implicated in neurodegenerative diseases, muscle disorders, and cardiovascular conditions.
SLC8A3 antibodies are essential tools for studying the expression, localization, and function of NCX3 in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect NCX3 in tissue samples or cultured cells. Research utilizing SLC8A3 antibodies has shed light on its neuroprotective roles under ischemic stress, involvement in calcium signaling during muscle contraction, and potential contributions to diseases like Alzheimer's and Parkinson's.
Commercial SLC8A3 antibodies are typically raised in hosts such as rabbits or mice, with specificity validated via knockout controls or peptide blocking assays. Their applications extend to exploring therapeutic strategies targeting calcium dysregulation, making them indispensable in molecular and cellular biology research.
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