| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | ALL; CML; PHL; BCR1; D22S11; D22S662 |
| Entrez GeneID | 613 |
| clone | 1E11G12 |
| WB Predicted band size | 142.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human BCR (AA: 139-280) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于NDRG2抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*NDRG2 expression correlates with neuroglial differentiation and predicts poor prognosis in glioma*
**作者**：Zhang Y, et al.
**摘要**：该研究利用NDRG2抗体进行免疫组化分析，发现NDRG2在胶质瘤中表达下调，且与肿瘤分级和患者不良预后相关，提示其可能作为神经胶质细胞分化的标志物。
2. **文献名称**：*Development and application of a monoclonal antibody specific for human NDRG2 in Western blot and immunohistochemistry*
**作者**：Chen X, et al.
**摘要**：研究团队开发了一种高特异性抗人NDRG2的单克隆抗体，验证了其在Western blot和免疫组化中的应用，并证实NDRG2在正常组织中广泛表达，但在多种癌症中表达异常。
3. **文献名称**：*NDRG2 interacts with HIF-1α to enhance cellular hypoxic tolerance by regulating mitochondrial function*
**作者**：Li H, et al.
**摘要**：通过NDRG2抗体进行免疫共沉淀(Co-IP)实验，发现NDRG2与HIF-1α相互作用，调控线粒体功能，从而增强细胞在低氧环境下的存活能力，揭示了其在缺氧应激中的分子机制。
4. **文献名称**：*NDRG2 suppresses Alzheimer’s disease-like pathology by promoting microglial Aβ clearance*
**作者**：Wang L, et al.
**摘要**：研究使用NDRG2抗体在小鼠脑组织中进行免疫荧光染色，发现NDRG2通过激活小胶质细胞清除β淀粉样蛋白(Aβ)，延缓阿尔茨海默病病理进程。
The NDRG2 (N-Myc downstream-regulated gene 2) antibody is a crucial tool for studying the NDRG2 protein, a member of the NDRG family involved in cell differentiation, stress response, and tumor suppression. NDRG2 is widely expressed in tissues such as the brain, kidney, and heart, and is regulated by hypoxia, DNA damage, and hormonal signals. Unlike its homolog NDRG1. NDRG2 is associated with distinct pathways, including HIF-1 and p53. and plays roles in inhibiting tumor progression, modulating autophagy, and maintaining cellular homeostasis. Its dysregulation has been linked to cancers, neurodegenerative disorders (e.g., Alzheimer’s), and metabolic diseases.
NDRG2 antibodies are essential for detecting protein expression, localization (cytoplasmic/nuclear), and post-translational modifications. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore NDRG2's role in disease mechanisms. For example, reduced NDRG2 levels in gliomas or Alzheimer’s brain tissues highlight its tumor-suppressive and neuroprotective functions. Both polyclonal and monoclonal antibodies are available, with specificity validated via knockout controls or siRNA silencing. Commercial suppliers (e.g., Abcam, CST) provide antibodies for research, though optimization for specific applications is often required. Reliable NDRG2 antibodies are vital for advancing studies in cancer biology, neurology, and therapeutic target discovery.
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