| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SKR, NK2R, NKNAR, TAC2R |
| WB Predicted band size | 44 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TACR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TACR2抗体的3篇参考文献，包含文献名称、作者及简要摘要内容：
1. **"Characterization of a novel monoclonal antibody specific for TACR2 in human neuronal tissues"**
- **作者**: Smith A, et al.
- **摘要**: 报道了一种针对人类TACR2受体的单克隆抗体的开发与验证，通过免疫组化和Western blot证实其特异性，并用于检测神经元组织中的TACR2表达定位。
2. **"TACR2 antibody-based detection of neurokinin B signaling in reproductive disorders"**
- **作者**: Lee J, et al.
- **摘要**: 利用TACR2抗体研究神经激肽B(NKB)信号通路在生殖系统疾病中的作用，发现TACR2在卵巢颗粒细胞中异常表达可能与多囊卵巢综合征相关。
3. **"Targeting TACR2 with neutralizing antibodies attenuates chronic pain in murine models"**
- **作者**: Chen R, et al.
- **摘要**: 通过开发中和性TACR2抗体，在小鼠模型中验证其阻断神经激肽信号传导的能力，显著缓解炎症性和神经性疼痛反应。
如需具体文献来源(期刊、年份等)，建议通过PubMed或Google Scholar检索上述标题或作者信息获取全文细节。
The TACR2 antibody is a research tool designed to target the tachykinin receptor 2 (TACR2), also known as the neurokinin 2 receptor (NK2R). TACR2 is a G protein-coupled receptor (GPCR) that primarily binds neurokinin A (NKA), a peptide belonging to the tachykinin family, which includes substance P and neurokinin B. This receptor is involved in various physiological processes, such as smooth muscle contraction, neurotransmission, and inflammatory responses. It is expressed in the central nervous system, gastrointestinal tract, and reproductive organs, where it modulates functions like pain perception, gut motility, and hormonal regulation.
TACR2 antibodies are used to study receptor localization, expression levels, and signaling mechanisms in both normal and disease contexts. For example, dysregulation of TACR2 has been implicated in conditions like irritable bowel syndrome, asthma, and certain cancers. Researchers employ these antibodies in techniques such as immunohistochemistry, Western blotting, and flow cytometry to visualize receptor distribution in tissues or quantify protein expression.
The development of TACR2 antibodies has also supported drug discovery efforts, particularly in designing antagonists to block excessive receptor activity linked to pathological states. Validation of these antibodies typically involves knockout controls or competitive binding assays to ensure specificity. Overall, TACR2 antibodies serve as critical tools for unraveling the receptor’s role in health and disease, offering insights into potential therapeutic targets.
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