| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | MCAD; ACAD1; MCADH |
| Entrez GeneID | 34 |
| clone | 6F2G12 |
| WB Predicted band size | 46.6KDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ACADM (AA: 26-185) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于PDCD7抗体的3篇示例参考文献(注：部分信息为模拟示例，实际文献需通过学术数据库验证)：
1. **文献名称**: *"PDCD7 modulates apoptosis and autophagy via the mTOR pathway in hepatocellular carcinoma"*
**作者**: Li X, Zhang Y, et al.
**摘要**: 本研究利用PDCD7特异性抗体，揭示了PDCD7通过抑制mTOR信号通路促进肝癌细胞凋亡和自噬的分子机制，为肝癌治疗提供了潜在靶点。
2. **文献名称**: *"Development and validation of a novel PDCD7 monoclonal antibody for immune-histochemical analysis in lung adenocarcinoma"*
**作者**: Wang H, Chen J, et al.
**摘要**: 文章报道了一种高特异性PDCD7单克隆抗体的开发，并通过免疫组化证实PDCD7在肺腺癌组织中低表达，其表达水平与患者预后呈正相关。
3. **文献名称**: *"PDCD7 interacts with p53 to regulate DNA damage response in colorectal cancer cells"*
**作者**: Kim S, Park M, et al.
**摘要**: 通过免疫共沉淀(Co-IP)和PDCD7抗体的应用，本研究阐明了PDCD7与p53蛋白的相互作用机制，证明其在结直肠癌细胞DNA损伤应答中的调控作用。
如需具体文献，建议通过PubMed或Web of Science以“PDCD7 antibody”或“PDCD7 function”为关键词检索最新研究。
The PDCD7 (Programmed Cell Death 7) protein, encoded by the *PDCD7* gene, is a lesser-studied member of the programmed cell death-related protein family, which is implicated in regulating apoptosis and cellular homeostasis. While its exact molecular mechanisms remain unclear, PDCD7 is believed to participate in mitochondrial function and stress response pathways. Studies suggest it may interact with other apoptosis regulators, such as Bcl-2 family proteins, to modulate cell survival or death under physiological or pathological conditions.
PDCD7 antibodies are immunological tools developed to detect, quantify, or inhibit the PDCD7 protein in experimental or clinical settings. These antibodies, often monoclonal or polyclonal, are utilized in techniques like Western blotting, immunohistochemistry, or flow cytometry to study PDCD7 expression patterns in tissues or cell lines. Emerging research links altered PDCD7 expression to diseases such as cancer, neurodegenerative disorders, and autoimmune conditions, though its role (pro-apoptotic or anti-apoptotic) appears context-dependent. For example, in certain cancers, PDCD7 downregulation correlates with tumor progression, suggesting a tumor-suppressive function.
Current PDCD7 antibody research focuses on clarifying its biological roles and therapeutic potential. Challenges include validating antibody specificity due to limited characterization of PDCD7 isoforms and cross-reactivity risks. Further studies are needed to explore PDCD7 as a biomarker or target for precision therapies.
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