| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | PDGF1, PDGF-A |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PDGFA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于PDGFA抗体的参考文献示例(注：以下为模拟内容，具体文献请通过学术数据库核实)：
---
1. **文献名称**：*Targeting PDGFA signaling in glioblastoma with a novel monoclonal antibody*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种靶向PDGFA的单克隆抗体，证实其可通过阻断PDGF/PDGFRα信号通路抑制胶质母细胞瘤的增殖和血管生成，显著延长小鼠模型生存期。
2. **文献名称**：*Anti-PDGFA therapy attenuates pulmonary fibrosis in a murine model*
**作者**：Chen L, et al.
**摘要**：通过使用PDGFA中和抗体，抑制了小鼠肺纤维化模型中的成纤维细胞活化和胶原沉积，为特发性肺纤维化治疗提供了潜在策略。
3. **文献名称**：*Mechanistic insights into PDGFA-mediated tumor metastasis and antibody blockade*
**作者**：Wang Y, et al.
**摘要**：该研究揭示了PDGFA通过激活PI3K/AKT通路促进癌细胞迁移的机制，并证明特异性抗体可有效阻断这一过程，抑制乳腺癌转移。
4. **文献名称**：*A humanized anti-PDGFA antibody for dermatological applications*
**作者**：Kim S, et al.
**摘要**：报道了一种人源化PDGFA抗体，在银屑病模型中显示可减少表皮增厚和炎症细胞浸润，提示其在慢性皮肤病中的治疗潜力。
---
如需真实文献，建议通过**PubMed**或**Web of Science**检索关键词(如“PDGFA antibody therapy”、“PDGFA inhibitor”)，并筛选近年高影响力论文。
The platelet-derived growth factor alpha (PDGFA) is a key member of the PDGF family, which plays critical roles in cell proliferation, migration, survival, and tissue development by binding to its receptor PDGFRα. PDGFA is essential during embryogenesis, particularly in neural crest, lung, and intestinal development. In adults, it regulates wound healing, angiogenesis, and connective tissue homeostasis. Dysregulation of PDGFA signaling is implicated in pathological conditions, including cancer (e.g., glioblastoma, lung, and breast cancers), fibrosis, and cardiovascular diseases, where it promotes tumor growth, stromal activation, and abnormal tissue remodeling.
PDGFA antibodies are vital tools for detecting PDGFA expression and activation in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to study PDGFA localization, protein levels, and signaling dynamics in cells and tissues. These antibodies also facilitate functional studies, such as blocking PDGFA-PDGFRα interactions to explore therapeutic targeting. Monoclonal antibodies offer high specificity, while polyclonal versions may detect multiple isoforms. Validated PDGFA antibodies are crucial for ensuring reproducibility in studies exploring PDGFA's role in disease mechanisms or its potential as a biomarker. Therapeutic anti-PDGFA agents are under investigation to inhibit oncogenic or fibrotic pathways, highlighting the antibody's translational relevance.
×
