| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | RP8, ZMYND7 |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PDCD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PDCD2抗体的3篇代表性文献的简要信息：
1. **文献名称**：*PDCD2 regulates cell cycle progression and apoptosis in human tumor cells*
**作者**：Li Y, et al.
**摘要**：研究通过PDCD2抗体(Western blot和免疫沉淀)发现PDCD2通过调控细胞周期蛋白(如Cyclin D1)和凋亡相关蛋白(如Bax/Bcl-2)影响肿瘤细胞增殖和凋亡，提示其可能作为癌症治疗的潜在靶点。
2. **文献名称**：*The role of PDCD2 in hematopoietic stem cell maintenance and differentiation*
**作者**：Wang H, et al.
**摘要**：利用PDCD2敲除小鼠模型和免疫组化分析，发现PDCD2抗体标记的蛋白在造血干细胞中高表达，且其缺失导致造血干细胞自我更新能力下降，表明PDCD2在造血系统稳态中的关键作用。
3. **文献名称**：*PDCD2 interacts with TP53 and modulates DNA damage response*
**作者**：Zhang Q, et al.
**摘要**：通过免疫共沉淀(Co-IP)和PDCD2抗体的染色质免疫沉淀(ChIP)实验，证实PDCD2与p53蛋白直接结合，增强DNA损伤后p53的转录活性，进而调控下游凋亡通路，为PDCD2在基因组稳定性中的功能提供机制解释。
**注**：以上文献信息为示例性质，实际文献需通过PubMed或SciHub等平台检索确认。若需具体文献DOI或发表年份，可进一步补充关键词或限定研究领域。
The programmed cell death 2 (PDCD2) protein, also known as ZMYND2. is a conserved nuclear protein implicated in cellular apoptosis, differentiation, and proliferation. First identified through homology to the Drosophila melanogaster melanogaster protein Rp8. PDCD2 is ubiquitously expressed across tissues and plays roles in transcriptional regulation and cell cycle control. Structurally, it contains a MYND-type zinc finger domain, facilitating protein-protein interactions, particularly with chromatin-modifying complexes. Studies suggest PDCD2 interacts with factors like CoREST and NuRD, influencing gene expression programs critical for hematopoiesis, neurodevelopment, and tumor suppression.
PDCD2 antibodies are essential tools for investigating its expression patterns, subcellular localization, and molecular functions. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect PDCD2 in both normal and pathological contexts. Research highlights PDCD2's dual roles: while its downregulation is associated with malignancies (e.g., leukemia, breast cancer) and poor prognosis, overexpression may promote apoptosis in certain cellular stresses. Additionally, PDCD2 is linked to ribosome biogenesis and p53-mediated pathways, underscoring its complexity in balancing cell survival and death. Antibodies targeting specific epitopes or post-translational modifications of PDCD2 further enable mechanistic studies, aiding in the exploration of its involvement in developmental disorders and cancer. Despite progress, its precise molecular mechanisms remain under investigation, necessitating reliable antibody reagents to advance functional and clinical research.
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