| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | RAD; RAD1; REM3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human RRAD |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于RRAD抗体的3篇参考文献示例(注：以下信息为模拟生成，非真实文献，供参考)：
---
1. **文献名称**: *"RRAD as a Potential Biomarker in Triple-Negative Breast Cancer: Immunohistochemical Analysis Using a Novel Monoclonal Antibody"*
**作者**: Lee, H. et al.
**摘要**: 本研究开发了一种特异性识别RRAD蛋白的单克隆抗体，并通过免疫组化分析发现RRAD在三阴性乳腺癌组织中高表达，且与患者预后不良相关。抗体验证实验包括Western blot和免疫荧光，证实其在临床样本中的可靠性。
2. **文献名称**: *"Role of RRAD in Insulin Resistance: Antibody-Based Knockdown Validation in Diabetic Models"*
**作者**: Zhang, Y. et al.
**摘要**: 通过构建RRAD特异性抗体，研究团队在糖尿病小鼠模型中证明RRAD通过干扰胰岛素受体信号通路加剧胰岛素抵抗。抗体用于组织切片染色和蛋白质印迹，结果显示RRAD在脂肪细胞中的异常表达与代谢紊乱相关。
3. **文献名称**: *"RRAD Promotes Tumor Angiogenesis via EGFR Signaling: Evidence from Antibody-Mediated Protein Interaction Studies"*
**作者**: Gupta, S. et al.
**摘要**: 利用抗RRAD抗体进行免疫共沉淀(Co-IP)和免疫组织化学分析，研究发现RRAD通过结合EGFR并激活下游MAPK通路促进肿瘤血管生成。抗体特异性验证显示其在多种癌细胞系中具有高亲和力。
---
如需真实文献，建议在PubMed或Google Scholar中检索关键词：**"RRAD antibody" + "cancer/diabetes"**，并筛选近5年内的研究。部分实际研究可能聚焦于RRAD在代谢疾病或肿瘤中的分子机制，抗体多用于蛋白质定位、表达量检测或功能抑制实验。
RRAD (Ras-related associated with diabetes) is a small GTP-binding protein encoded by the RRAD gene, initially identified for its role in insulin resistance and type 2 diabetes. Belonging to the Ras superfamily, RRAD regulates cellular processes such as glucose uptake, cell proliferation, and cytoskeletal organization. Its overexpression has been linked to impaired insulin signaling in skeletal muscle and adipose tissue, making it a potential biomarker for metabolic disorders. Recent studies also implicate RRAD in cancer progression, particularly in breast, lung, and gastric cancers, where it modulates tumor growth, metastasis, and chemoresistance through interactions with signaling pathways like PI3K/Akt and MAPK.
RRAD antibodies are essential tools for detecting and quantifying RRAD protein expression in research. They enable investigations into its tissue-specific distribution, post-translational modifications, and interactions with other proteins. Polyclonal and monoclonal RRAD antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate RRAD's dual role in metabolic diseases and oncology, offering insights into its molecular mechanisms and therapeutic targeting. Validated antibodies are critical for ensuring specificity, particularly given RRAD's structural homology with other GTPases. Ongoing research aims to develop RRAD-targeted therapies and diagnostic applications.
×
