首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal SLC24A1 Antibody

  • 中文名： SLC24A1抗体
  • 别    名： NCKX; RODX; NCKX1; CSNB1D; HsT17412
货号: IPDX11349
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesNCKX; RODX; NCKX1; CSNB1D; HsT17412
WB Predicted band size121 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Rat
ImmunogenSynthetic peptide of human SLC24A1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是3篇涉及SLC24A1抗体的文献示例(注：部分信息为示例性描述，具体文献需通过数据库验证)：

1. **文献名称**：*SLC24A1 regulates intracellular calcium homeostasis in retinal pigment epithelium*

**作者**：Smith A et al. (2015)

**摘要**：使用SLC24A1特异性抗体通过免疫荧光和Western blot证实该蛋白在视网膜色素上皮细胞中的定位，发现其缺陷导致钙离子外流异常。

2. **文献名称**：*Functional characterization of SLC24A1 variants in skin pigmentation disorders*

**作者**：Zhang L et al. (2018)

**摘要**：采用抗SLC24A1抗体进行免疫组化分析，发现该蛋白在黑色素细胞中高表达，其突变与色素沉着异常相关。

3. **文献名称**：*SLC24A1-mediated calcium transport in kidney tubular cells*

**作者**：Gupta R et al. (2020)

**摘要**：通过SLC24A1抗体抑制实验证明其在肾小管细胞钙离子重吸收中的关键作用，并关联于肾病模型中的电解质失衡。

(注：以上文献为假设性示例，实际研究需以PubMed/Google Scholar检索为准。)

背景信息

The SLC24A1 gene encodes a protein belonging to the solute carrier family 24 (SLC24), which functions as a sodium/potassium/calcium exchanger. Primarily expressed in retinal pigment epithelium (RPE) and melanocytes, SLC24A1 plays a critical role in regulating intracellular calcium levels, influencing processes like melanin synthesis and photoreceptor maintenance. Mutations in SLC24A1 are linked to ocular disorders, including autosomal recessive congenital stationary night blindness (CSNB), due to disrupted calcium homeostasis in retinal cells. Antibodies targeting SLC24A1 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate SLC24A1's role in melanosome maturation, retinal signaling, and associated diseases. Validation of specificity (e.g., knockout controls) ensures reliable detection in research models. Current studies leverage SLC24A1 antibodies to explore therapeutic strategies for vision-related disorders and pigmentary abnormalities, highlighting their importance in both basic and translational research.

客户数据及评论

折叠内容

大包装询价

×