Rabbit Polyclonal SLC24A1 Antibody

The SLC24A1 gene encodes a protein belonging to the solute carrier family 24 (SLC24), which functions as a sodium/potassium/calcium exchanger. Primarily expressed in retinal pigment epithelium (RPE) and melanocytes, SLC24A1 plays a critical role in regulating intracellular calcium levels, influencing processes like melanin synthesis and photoreceptor maintenance. Mutations in SLC24A1 are linked to ocular disorders, including autosomal recessive congenital stationary night blindness (CSNB), due to disrupted calcium homeostasis in retinal cells. Antibodies targeting SLC24A1 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate SLC24A1's role in melanosome maturation, retinal signaling, and associated diseases. Validation of specificity (e.g., knockout controls) ensures reliable detection in research models. Current studies leverage SLC24A1 antibodies to explore therapeutic strategies for vision-related disorders and pigmentary abnormalities, highlighting their importance in both basic and translational research.