Rabbit Polyclonal SLC32A1 Antibody

The SLC32A1 gene encodes vesicular GABA transporter (VGAT), a transmembrane protein critical for inhibitory neurotransmission. VGAT transports the neurotransmitters GABA and glycine into synaptic vesicles, utilizing the proton gradient across vesicular membranes. This process is essential for the storage and subsequent release of these inhibitory neurotransmitters at synapses in the central and peripheral nervous systems. SLC32A1 antibodies are immunological tools designed to detect and study VGAT expression, localization, and function. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize VGAT distribution in neurons and neuroendocrine cells. Research involving SLC32A1 antibodies has advanced understanding of inhibitory circuit organization, synaptic plasticity, and pathologies linked to GABAergic dysfunction, such as epilepsy, anxiety disorders, and schizophrenia. Specificity and validation of these antibodies are crucial, as they enable precise identification of VGAT in complex tissues, aiding studies on neurotransmitter recycling, vesicle dynamics, and drug-target interactions. By facilitating the exploration of GABAergic and glycinergic systems, SLC32A1 antibodies remain pivotal in neuroscience and neuropharmacology research.