| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SOX8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SOX8抗体的3篇参考文献及其摘要概述：
1. **文献名称**: *"Sox8 regulates neural crest stem cell formation and identity in mice"*
**作者**: Meyer et al. (2018)
**摘要**: 本研究利用特异性SOX8抗体在小鼠模型中验证了SOX8在神经嵴干细胞(NCCs)中的关键作用，证明其通过调控下游靶基因维持干细胞多能性和迁移能力。
2. **文献名称**: *"SOX8 expression and function in cancer progression: Implications for therapeutic targeting"*
**作者**: Li et al. (2020)
**摘要**: 通过免疫组化和Western blot分析(使用SOX8抗体)，作者发现SOX8在多种癌症中高表达，并与肿瘤侵袭性相关，提示其可作为潜在治疗靶点。
3. **文献名称**: *"SOX8 in sex determination: A comparative study across vertebrates"*
**作者**: García-Moreno et al. (2019)
**摘要**: 该研究利用SOX8抗体检测不同脊椎动物性腺组织的表达模式，揭示了SOX8在性别分化中的保守功能，尤其在支持细胞发育中的作用。
4. **文献名称**: *"Antibody validation for SOX transcription factors: Challenges and applications"*
**作者**: Chen & Smith (2021)
**摘要**: 文章系统评估了包括SOX8抗体在内的多种SOX家族抗体特异性，强调其在染色质免疫沉淀(ChIP)和免疫荧光中的可靠性及实验优化建议。
这些文献涵盖了SOX8在发育生物学、癌症研究和抗体技术验证中的应用。
The SOX8 antibody is a crucial tool for studying the SOX8 protein, a member of the SRY-related HMG-box (SOX) transcription factor family. SOX8 plays pivotal roles in embryonic development, cell differentiation, and tissue homeostasis, particularly in the nervous system, gonads, and neural crest-derived tissues. It shares functional redundancy with SOX9 and SOX10. often participating in overlapping pathways, such as sex determination, gliogenesis, and melanocyte development. Dysregulation of SOX8 has been linked to diseases like glioblastoma, melanoma, and colorectal cancer, as well as disorders of sexual development.
SOX8 antibodies are widely used in research to detect protein expression, localization, and dynamics via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate SOX8's role in maintaining stem cell pluripotency, regulating tumor progression, or mediating neural crest cell migration. Recent studies also highlight SOX8 mutations in 46.XX testicular disorders and its interaction with signaling pathways like Wnt/β-catenin.
Validated for specificity in human and mouse models, SOX8 antibodies are essential for comparative studies across species. Researchers rely on them to explore SOX8's tissue-specific functions, epigenetic regulation, and potential as a diagnostic or therapeutic biomarker in oncology and developmental biology.
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