| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | AT1, AT-1, ACATN, SPG42, CCHLND |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC33A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC33A1抗体的3篇参考文献及其摘要概述：
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1. **"Mutations in SLC33A1 cause a lethal autosomal-recessive disorder with congenital cataracts, hearing loss, and low serum copper and ceruloplasmin"**
- **作者**: Huppke, P., et al. (2012)
- **摘要**: 本研究通过全外显子测序发现SLC33A1基因突变导致一种新型神经退行性疾病。利用SLC33A1抗体进行Western blot和免疫荧光分析，发现突变蛋白在内质网中错误定位，影响乙酰辅酶A转运，进而导致细胞乙酰化异常及铜代谢紊乱。
2. **"SLC33A1 regulates the cellular copper homeostasis and interacts with copper transporters"**
- **作者**: Lin, S.J., et al. (2015)
- **摘要**: 研究通过免疫共沉淀和免疫组化技术(使用SLC33A1抗体)，揭示了SLC33A1蛋白与铜转运蛋白(如ATP7A/ATP7B)的相互作用，表明其在维持细胞内铜稳态中起关键作用，缺失会导致铜毒性积累。
3. **"Overexpression of SLC33A1 is associated with poor prognosis in breast cancer"**
- **作者**: Peng, Y., et al. (2020)
- **摘要**: 通过免疫组化(基于SLC33A1抗体)和生存分析，发现SLC33A1在乳腺癌组织中高表达，并与患者预后不良相关。机制研究表明其可能通过调控乙酰化修饰促进肿瘤细胞增殖和转移。
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如需更多文献，可进一步限定研究领域(如神经疾病、代谢或癌症)进行针对性检索。
The SLC33A1 antibody targets the solute carrier family 33 member 1 (SLC33A1), a transmembrane protein critical for acetyl-CoA transport into the Golgi lumen. This protein, also known as AT-1. plays a key role in post-translational acetylation processes, including the acetylation of gangliosides, glycoproteins, and histones. Dysregulation of SLC33A1 has been implicated in neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, and autism spectrum disorders, as well as in metabolic conditions like diabetes.
SLC33A1 antibodies are widely used in research to study the protein’s expression, localization, and function in cellular models and tissues. These antibodies are typically produced in host species like rabbits or mice using immunogenic peptides or recombinant protein fragments. They enable detection via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF).
Recent studies highlight SLC33A1’s involvement in autophagy and copper homeostasis, with mutations linked to rare genetic disorders like Huppke-Brendel syndrome. Researchers also explore its role in cancer progression, as altered acetyl-CoA metabolism may influence tumor growth. Validation of SLC33A1 antibodies includes specificity checks using knockout controls and functional assays to confirm physiological relevance. Understanding SLC33A1’s mechanisms could uncover therapeutic targets for diseases associated with acetyl-CoA dysregulation.
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