| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | SS4R; SS4-R; SS-4-R |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SSTR4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SSTR4抗体的3篇参考文献示例(文献信息为虚构示例，实际文献需通过学术数据库验证)：
1. **文献名称**：*"Selective expression of somatostatin receptor subtype 4 in human neuroendocrine tumors"*
**作者**：Reubi JC, et al.
**摘要**：研究了SSTR4在多种神经内分泌肿瘤中的特异性表达，发现其与肿瘤分化程度相关，提示SSTR4抗体可能作为诊断标志物。
2. **文献名称**：*"Development of a monoclonal antibody targeting SSTR4 for in vitro characterization"*
**作者**：Kumar A, et al.
**摘要**：报道了一种高特异性SSTR4单克隆抗体的开发，验证了其在免疫组化和流式细胞术中的应用潜力。
3. **文献名称**：*"SSTR4-mediated signaling pathways in glioblastoma cells revealed by antibody-based inhibition"*
**作者**：Cescato R, et al.
**摘要**：利用SSTR4抗体阻断受体功能，揭示了其在胶质母细胞瘤细胞中调控MAPK/ERK信号通路的作用机制。
4. **文献名称**：*"Comparative analysis of SSTR4 antibody performance in molecular imaging"*
**作者**：Korner M, et al.
**摘要**：比较了不同SSTR4抗体在肿瘤分子成像中的灵敏度和特异性，为临床影像学应用提供参考。
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**提示**：实际研究中建议通过PubMed或Google Scholar以关键词“SSTR4 antibody”或“somatostatin receptor 4”检索最新文献，并注意验证抗体货号及研究背景的匹配性。
Somatostatin receptor type 4 (SSTR4) is a G protein-coupled receptor (GPCR) that binds somatostatin, a neuropeptide regulating hormone secretion, cell proliferation, and neurotransmission. SSTR4. one of five receptor subtypes (SSTR1-5), is primarily expressed in the central nervous system, pituitary gland, and peripheral tissues, modulating cAMP pathways and ion channel activity. Its role in physiological processes—such as pain perception, cognitive function, and inflammatory responses—has drawn interest in neurological and endocrine research.
SSTR4-specific antibodies are critical tools for studying receptor localization, expression levels, and signaling mechanisms in both normal and pathological states. These antibodies enable techniques like immunohistochemistry, Western blotting, and flow cytometry. Research highlights SSTR4's potential involvement in neurodegenerative diseases (e.g., Alzheimer's), epilepsy, and neuroendocrine tumors, where receptor dysregulation may contribute to disease progression. Additionally, SSTR4-targeted therapies, including peptide-drug conjugates or radiolabeled ligands, are under exploration, necessitating precise antibody validation to ensure specificity and minimize cross-reactivity with other SSTR subtypes. Recent advances in antibody engineering, such as monoclonal or recombinant formats, have improved detection sensitivity, supporting translational studies aiming to exploit SSTR4 as a biomarker or therapeutic target.
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