| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HLTS |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SOX18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SOX18抗体的3篇参考文献及其摘要概括：
1. **"SOX18 regulates sprouting angiogenesis via RGS3 and PDE5 in endothelial cells"**
- **作者**: Xu C. et al. (2020)
- **摘要**：研究通过SOX18抗体染色发现，SOX18通过调控RGS3和PDE5基因表达，影响内皮细胞迁移和血管生成，为治疗血管相关疾病提供新靶点。
2. **"The transcription factor Sox18 is required for lymphatic vessel development in mice"**
- **作者**: Francois M. et al. (2008)
- **摘要**：利用特异性SOX18抗体证实，Sox18基因缺陷小鼠因淋巴管内皮细胞分化受阻导致淋巴系统发育异常，揭示了SOX18在淋巴管形成中的关键作用。
3. **"SOX18 promotes melanoma progression through regulation of angiogenesis and immune evasion"**
- **作者**: Duong T. et al. (2019)
- **摘要**：通过免疫组化(SOX18抗体)及功能实验，发现SOX18通过激活VEGF通路促进肿瘤血管生成，并抑制免疫微环境，驱动黑色素瘤恶化。
**Background of SOX18 Antibody**
The SOX18 antibody is a research tool targeting the SOX18 protein, a member of the SOX (SRY-related HMG-box) transcription factor family. SOX18 belongs to the SOXF subgroup (SOX7. SOX17. SOX18) and plays critical roles in developmental processes, particularly in vascular and lymphatic endothelial cell regulation. It contains a conserved high-mobility group (HMG) domain that enables DNA binding and interaction with transcriptional co-regulators.
SOX18 is essential for blood and lymphatic vessel formation during embryogenesis. Mutations in *SOX18* are linked to human vascular disorders, such as hypotrichosis-lymphedema-telangiectasia syndrome, and its dysregulation is implicated in cancer progression, inflammation, and atherosclerosis. In tumors, SOX18 may promote angiogenesis and lymphangiogenesis, facilitating metastasis.
Antibodies against SOX18 are widely used in molecular biology to detect and quantify the protein via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They help elucidate SOX18’s expression patterns, subcellular localization, and interactions in normal and diseased tissues. Commercial SOX18 antibodies are typically validated for specificity in human, mouse, or rat samples.
Research involving SOX18 antibodies contributes to understanding vascular development, tumor microenvironments, and regenerative medicine. Additionally, they hold potential for therapeutic targeting in diseases driven by aberrant vascular growth or lymphatic dysfunction. However, challenges remain in optimizing antibody specificity and reproducibility across experimental models.
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