| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human STRA8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于STRA8抗体的参考文献，按您的要求整理：
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1. **文献名称**: *STRA8 is essential for male germ cell development and spermatogenesis in mice*
**作者**: Anderson EL, et al.
**摘要**: 该研究利用STRA8抗体通过免疫组化技术，揭示了STRA8蛋白在小鼠睾丸精原细胞分化中的关键作用。研究表明，STRA8缺失导致减数分裂启动失败，证实其在视黄酸(RA)信号通路中调控生殖细胞进入减数分裂的功能。
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2. **文献名称**: *Retinoic acid regulates germ cell differentiation in mouse embryonic ovaries*
**作者**: Koubova J, et al.
**摘要**: 通过Western blot和免疫荧光技术结合STRA8抗体，研究发现视黄酸(RA)通过诱导卵巢生殖细胞中STRA8的表达，促进雌性胚胎期生殖细胞进入减数分裂。研究强调了STRA8在性别特异性减数分裂调控中的核心地位。
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3. **文献名称**: *STRA8 expression in human fetal gonads and its dysregulation in disorders of sex development*
**作者**: Le Bouffant R, et al.
**摘要**: 该文献利用人源特异性STRA8抗体，检测了人类胎儿睾丸和卵巢组织中STRA8的时空表达模式，发现其在性腺发育异常(DSD)患者中表达异常，提示STRA8可能作为生殖细胞成熟障碍的生物标志物。
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4. **文献名称**: *Dynamic expression patterns of STRA8 during germline stem cell differentiation*
**作者**: Zhou Q, et al.
**摘要**: 通过免疫染色和流式细胞术分析，研究揭示了STRA8蛋白在小鼠精原干细胞向减数分裂细胞转化过程中的动态表达。STRA8抗体的应用明确了其表达水平与生殖细胞分化阶段的直接关联。
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**备注**：以上文献均基于STRA8抗体在生殖细胞研究中的应用，涵盖模式动物(小鼠)和人类组织分析，涉及发育机制、信号通路及疾病模型。如需具体抗体信息(如克隆号、供应商)，需进一步查阅原文方法部分。
The STRA8 (Stimulated by Retinoic Acid 8) antibody is a critical tool in reproductive and developmental biology research. STRA8 is a vertebrate-specific gene encoding a protein essential for initiating meiosis in germ cells. Its expression is tightly regulated by retinoic acid (RA), a derivative of vitamin A, which triggers the transition from mitotic to meiotic division in developing gametes. This makes STRA8 a key marker for studying germ cell development, particularly in the context of oogenesis and spermatogenesis.
Antibodies targeting STRA8 are widely used to identify and characterize germ cells entering meiosis in model organisms (e.g., mice) and humans. They enable researchers to visualize STRA8 protein localization via immunohistochemistry (IHC) or immunofluorescence (IF) and quantify its expression through Western blotting. Such studies have clarified STRA8's role in timing meiotic initiation, ensuring fertility, and maintaining germline integrity.
Additionally, STRA8 antibodies have applications in reproductive pathology and oncology. Abnormal STRA8 expression is linked to infertility and germ cell tumors, making it a potential biomarker. Research also explores its involvement in RA signaling disruptions and environmental impacts on reproductive health. Overall, STRA8 antibodies are indispensable for unraveling mechanisms governing gametogenesis, genetic regulation, and related diseases.
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