Rabbit Polyclonal TRPM7 Antibody

TRPM7 (Transient Receptor Potential Melastatin 7) is a bifunctional protein that combines an ion channel permeable to divalent cations (e.g., Mg²⁺, Ca²⁺) with a serine/threonine kinase domain. It plays critical roles in cellular magnesium homeostasis, cell proliferation, migration, and apoptosis. Dysregulation of TRPM7 has been linked to pathologies including neurodegenerative disorders, cardiovascular diseases, and cancer metastasis. TRPM7 antibodies are essential tools for studying its expression, localization, and functional mechanisms. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect TRPM7 in tissues or cultured cells. Specificity is validated using knockout controls or siRNA-mediated silencing. Research applications range from exploring TRPM7's involvement in ischemic stroke recovery to its impact on fibrosis or tumor invasiveness. Both monoclonal and polyclonal antibodies are available, with selection depending on experimental needs. Challenges include potential cross-reactivity with homologous family members (e.g., TRPM6) and ensuring proper membrane protein extraction due to TRPM7's localization. Recent studies also investigate TRPM7 as a therapeutic target, driving demand for reliable antibodies to assess modulation of its activity in disease models.